Selective activation of ectopic grey matter during motor task.

Full Abstract

The role of ectopic grey matter in neuronal migration disorders is still a matter of debate. Using fMRI we studied the activation pattern of ectopic and regular cortical neurons in a female patient with subcortical bilateral laminar heterotopia (double cortex syndrome) performing a simple motor task. We demonstrate a synchronous activation pattern of the motor cortex and the adjacent subcortical ectopic grey matter layer during finger-tapping. We also observed activation in the cerebellum ipsilaterally and in the basal ganglia contralaterally. The present findings are consistent with the hypothesis that ectopic neurons may be functionally integrated in motor circuits during repetitive voluntary movements.

Author information

Author/s: Draganski, B (B); Winkler, J (J); Flügel, D (D); May, A (A);

Affiliation: Department of Neurology, University of Regensburg, Universitätsstrasse 84, D-93053 Regensburg, Germany. bogdan.draganski(-atsign-)klinik.uni-regensburg.de

Journal and publication information

Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2004-Feb; vol 15 (issue 2) : pp 251-3

Dates: Created 2004/04/12; Completed 2004/06/10; Revised 2006/11/15;

PMID: 15076746, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.