Successful multi-vessel percutaneous coronary intervention with bivalirudin in a patient with severe hemophilia A: a case report and review of literature.

Full Abstract

We describe a 64-year-old male with severe hemophilia A (factor VIII-dependent), acute myocardial infarction (MI) and congestive heart failure (CHF) who underwent successful multi-vessel percutaneous coronary intervention (PCI). The patient was administered factor VIII transfusion to maintain activity levels between 60-80%. Anticoagulation during the PCI procedure was maintained with the direct thrombin inhibitor, bivalirudin. There were no procedural complications and the patient was discharged home the following day. These results suggest that bivalirudin may be used effectively in patients at very high risk of bleeding with enhanced procedural safety.

Author information

Author/s: Arora, Umesh K (UK); Dhir, Meeney (M); Cintron, Guillermo (G); Strom, Joel A (JA);

Affiliation: University of South Florida, Tampa, USA. umeen2111(-atsign-)aol.com

Journal and publication information

Publication Type: Case Reports; Journal Article; Review

Journal: The Journal of invasive cardiology (J Invasive Cardiol), published in United States. (Language: eng)

Reference: 2004-Jun; vol 16 (issue 6) : pp 330-2

Dates: Created 2004/05/24; Completed 2004/07/22; Revised 2004/11/17;

PMID: 15156005, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Angioplasty, Transluminal, Percutaneous Coronary
Anticoagulants - administration & dosage
Antithrombins - administration & dosage
Blood Component Transfusion
Coronary Angiography
Factor VIII - administration & dosage
Hemophilia A - complications; therapy
Hirudins - administration & dosage; analogs & derivatives

Hirudins - administration & dosage; analogs & derivatives
Humans
Male
Middle Aged
Myocardial Infarction - complications; therapy
Peptide Fragments - administration & dosage
Radiography, Interventional
Recombinant Proteins - administration & dosage

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Anticoagulants (0) ; Antithrombins (0) ; Hirudins (0) ; Peptide Fragments (0) ; Recombinant Proteins (0) ; bivalirudin (128270-60-0) ; Factor VIII (9001-27-8)

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