Research article summary (published 13 Jul 2004):

Synthesis and maturation of type I and type III collagens in endometrial adenocarcinoma.

Full Abstract

OBJECTIVE: The structure and distribution of type I and type III collagens in the extracellular matrix of malignant endometrium was evaluated for their roles in the development and progression of this neoplasm. STUDY DESIGN: Collagen synthesis and deposition in endometrial adenocarcinomas was determined by immunohistochemical analysis of type I and type III procollagen and verified by computer-assisted morphometry and in situ hybridization. RESULTS: In the stroma of well-differentiated adenocarcinomas increased intracellular collagen synthesis was observed in fibroblastic cells as well as increased extracellular formation of newly synthesized type I and type III procollagen. Collagen maturation was also rapid. In moderately differentiated tumors, destruction and dissolution occurred around invading islets, concomitantly with decreased deposits of both collagens, despite increases in corresponding mRNAs. In poorly differentiated neoplasms, solid epithelial islets coexisted with sparse and distinctly collagen-positive stroma. Poorly differentiated neoplasms also contained tumor cells exhibiting intracellular collagen staining as well as in situ hybridization signals. In highly malignant papillary adenocarcinomas, the tumor cells induced distinctly increased collagen synthesis and deposition of newly synthesized collagen but not the mature cross-linked protein. CONCLUSIONS: In malignancy, compression of surrounding stroma and a fibroproliferative response with increased collagen synthesis and deposition may prevent tumor growth. In more advanced lesions, stromal dissolution may permit tumor spread and in highly malignant lesions an abnormal stroma may promote neoplasm progression.

Author information

Author/s: Jussila, Tommi (T); Kauppila, Saila (S); Bode, Michaela (M); Tapanainen, Juha (J); Risteli, Juha (J); Risteli, Leila (L); Kauppila, Antti (A); Stenbäck, Frej (F);

Affiliation: Department of Pathology, University of Oulu, P.O. Box 5000 FIN-90014, Kajaanintie 52, 90220 Oulu, Finland.

Journal and publication information

Publication Type: Journal Article

Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol), published in Ireland. (Language: eng)

Reference: 2004-Jul; vol 115 (issue 1) : pp 66-74

Dates: Created 2004/06/29; Completed 2004/11/15; Revised 2004/11/17;

PMID: 15223168, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adenocarcinoma - chemistry; metabolism; pathology Adenocarcinoma, Papillary - chemistry; metabolism; pathology Adult Aged Aged, 80 and over Collagen Type I - biosynthesis; chemistry; genetics Collagen Type III - biosynthesis; chemistry; genetics Endometrial Neoplasms - chemistry; metabolism; pathology Endometrium - chemistry; metabolism Extracellular Matrix - chemistry; metabolism

Extracellular Matrix - chemistry; metabolism Female Humans Hysterectomy Immunohistochemistry In Situ Hybridization Middle Aged Peptide Fragments - analysis Procollagen - analysis RNA, Messenger - analysis

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; ICTP peptide (0) ; Peptide Fragments (0) ; Procollagen (0) ; RNA, Messenger (0) ; procollagen Type I N-terminal peptide (0) ; procollagen Type III-N-terminal peptide (0)

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