Synaptic plasticity and translation initiation.

Full Abstract

It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating synaptic strength. Our understanding of the translation-initiation process has expanded greatly in recent years. In this review, we discuss various aspects of translation initiation, as well as signaling pathways that might be involved in coupling neurotransmitter and neurotrophin receptors to the translation machinery during various forms of synaptic plasticity.

Author information

Author/s: Klann, Eric (E); Antion, Marcia D (MD); Banko, Jessica L (JL); Hou, Lingfei (L);

Affiliation: Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA. eklann(-atsign-)bcm.tmc.edu

Grants: NS34007 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

Journal: Learning & memory (Cold Spring Harbor, N.Y.) (Learn Mem), published in United States. (Language: eng)

Reference: -2004 Jul-Aug; vol 11 (issue 4) : pp 365-72

Dates: Created 2004/08/02; Completed 2004/09/23; Revised 2007/11/14;

PMID: 15254214, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
DNA-Binding Proteins - genetics; metabolism
Fragile X Mental Retardation Protein
Humans
Mice
Nerve Tissue Proteins - metabolism
Neuronal Plasticity - genetics; physiology
Neurons - physiology
Peptide Initiation Factors - metabolism

Protein Biosynthesis - physiology
RNA 5' Terminal Oligopyrimidine Sequence - physiology
RNA, Messenger - metabolism
RNA-Binding Proteins - metabolism
Ribosomal Protein S6 Kinases - metabolism
Signal Transduction - genetics; physiology
Synapses - genetics; physiology
Synaptic Transmission - genetics; physiology
Transcription Factors - genetics; metabolism

Associated Chemicals: CPEB protein, mouse (0) ; DNA-Binding Proteins (0) ; ELF4 protein, human (0) ; Elf4 protein, mouse (0) ; FMR1 protein, human (0) ; Fmr1 protein, mouse (0) ; Nerve Tissue Proteins (0) ; Peptide Initiation Factors (0) ; RNA, Messenger (0) ; RNA-Binding Proteins (0) ; Transcription Factors (0) ; Fragile X Mental Retardation Protein (139135-51-6) ; ELF2 protein, human (181233-60-3) ; Ribosomal Protein S6 Kinases (EC 2.7.1.37)

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