Effects of transforming growth factor-beta 1 on the early stages of healing of the Achilles tendon in a rat model.

Full Abstract

We studied the effects of transforming growth factor-beta 1 (TGF-beta 1) on the genetic expression of procollagen type I and III and its effects on structural properties in the early stages of healing in rat Achilles tendon. The Achilles tendons in 90 rats were transsected and repaired immediately. TGF-beta 1 dissolved in phosphate-buffered saline was injected locally at the repair site using two different doses, and outcomes in both groups were compared to that in the control group given phosphate-buffered saline only. Five animals in each group were killed at one, two, and four weeks postoperatively, and the healing tendon was evaluated. A dose-dependent increase in the expression of procollagen type I and III mRNA was found one week postoperatively. The failure load and stiffness of the healing tendon were increased by TGF-beta 1 at two and four weeks.

Author information

Author/s: Kashiwagi, Kenji (K); Mochizuki, Yu (Y); Yasunaga, Yuji (Y); Ishida, Osamu (O); Deie, Masataka (M); Ochi, Mitsuo (M);

Affiliation: Department of Orthopaedic Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. kkashiwagi(-atsign-)chugokuh.rofuku.go.jp

Journal and publication information

Publication Type: Journal Article

Journal: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi (Scand J Plast Reconstr Surg Hand Surg), published in Sweden. (Language: eng)

Reference: 2004-; vol 38 (issue 4) : pp 193-7

Dates: Created 2004/09/16; Completed 2005/04/12;

PMID: 15370799, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

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