Research article summary (published 3 Feb 2005):

Opiate modulation of monoamines in the chick forebrain: possible role in emotional regulation?

Full Abstract

Numerous studies have shown that the opiate system is crucially involved in emotionally guided behavior. In the present study, we focussed on the medio-rostral neostriatum/hyperstriatum ventrale (MNH) of the chick forebrain. This avian prefrontal cortex analogue is critically involved in auditory filial imprinting, a well-characterized juvenile emotional learning event. The high density of mu-opiate receptors expressed in the MNH led to the hypothesis that mu-opiate receptor-mediated processes may modulate the glutamatergic, dopaminergic, and/or serotonergic neurotransmission within the MNH and thereby have a critical impact on filial imprinting. Using microdialysis and pharmaco-behavioral approaches in young chicks, we demonstrated that: the systemic application of the mu-opiate receptor antagonist naloxone (5, 50 mg/kg) significantly increased extracellular levels of 5-HIAA and HVA; the systemic application of the specific mu-opiate receptor agonist DAGO (5 mg/kg) increased the levels of HVA and taurine, an effect that was antagonized by simultaneously applied naloxone (5 mg/kg); the local application of DAGO (1 mM) had no effects on 5-HIAA, HVA, glutamate, and taurine, however, the effects of systemically injected naloxone (5 mg/kg) were abolished by simultaneously applied DAGO (1 mM); the systemic application of naloxone (5 mg/kg) increased distress behavior (measured as the duration of distress vocalization during separation from the peer group). These results are in line with our hypothesis that the mu-opiate receptor-mediated modulation of serotonergic and dopaminergic neurotransmission alters the emotional and motivational status of the animal and thereby may play a modulatory role during filial imprinting in the newborn animal. 2004 Wiley Periodicals, Inc

Author information

Author/s: Baldauf, K (K); Braun, K (K); Gruss, M (M);

Affiliation: Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of neurobiology (J Neurobiol), published in United States. (Language: eng)

Reference: 2005-Feb; vol 62 (issue 2) : pp 149-63

Dates: Created 2004/12/14; Completed 2005/04/11; Revised 2006/11/15;

PMID: 15452850, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Analgesics, Opioid - pharmacology Animals Behavior, Animal - drug effects; physiology Biogenic Monoamines - metabolism Brain Chemistry - physiology Chickens Chromatography, High Pressure Liquid - methods Dose-Response Relationship, Drug Drug Interactions Emotions - drug effects; physiology Enkephalin, Ala(2)-MePhe(4)-Gly(5)- - pharmacology Female Glutamic Acid - metabolism

Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Male Microdialysis - methods Models, Biological Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Prosencephalon - drug effects; metabolism Statistics, Nonparametric Taurine - metabolism Time Factors Vocalization, Animal - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Analgesics, Opioid (0) ; Biogenic Monoamines (0) ; Narcotic Antagonists (0) ; Narcotics (0) ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- (100929-53-1) ; Taurine (107-35-7) ; Homovanillic Acid (306-08-1) ; Naloxone (465-65-6) ; Hydroxyindoleacetic Acid (54-16-0) ; Glutamic Acid (56-86-0)

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