Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich.

Full Abstract

This essay looks at the historical significance of two APS classic papers that are freely available online: Pitts RF and Alexander RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239-254, 1945 (http://ajplegacy.physiology.org/cgi/reprint/144/2/239). Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147: 138-154, 1946 (http://ajplegacy.physiology.org/cgi/reprint/147/1/138).

Author information

Author/s: Giebisch, Gerhard (G);

Affiliation: Dept. of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8026, USA. Gerhard.giebisch(-atsign-)yale.edu

Journal and publication information

Publication Type: Historical Article; Journal Article

Journal: American journal of physiology. Renal physiology (Am J Physiol Renal Physiol), published in United States. (Language: eng)

Reference: 2004-Nov; vol 287 (issue 5) : pp F864-5

Dates: Created 2004/10/11; Completed 2004/11/09; Revised 2004/11/17;

PMID: 15475538, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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