Research article summary (published 29 Sep 2004):

[Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study]

(Dinamicheskue izmeneniia serotonergicheskoi i dofaminergicheskoi aktivnosti mozga v protsesse razvitiia trevozhnoi depressii: éksperimental'noe issledovanie.)

Full Abstract

Chronic psychoemotional stress of social defeats produces development of experimental anxious depression in male mice similar to this disorder in humans. 5-HT and 5-HIAA levels, TPH and MAO A activities, 5-HT1A-receptors in different brain areas were investigated at different stages of development of experimental disorder. It has been shown that initial stage (3 days of social stress) is accompanied by increase of 5-HT level in some brain areas. Decreased 5-HIAA levels in the hippocampus, amygdala and nucleus accumbens were discovered at the stage of forming depression (10 days of social stress). Pharmacological desensitisation and decreased number of 5-HT1A-receptors were shown in frontal cortex and amygdala. At the stage of pronounced depression (20 days of stress), there were no differences in 5-HT and 5-HIAA levels in all brain areas (excluding hypothalamus) of depressive animals. However increased number of 5-HT1A-receptors and decreased affinity in amygdala and decreased TPH and MAOA activities in hippocampus were found in depressive mice. Hypofunction of serotonergic system is suggested at the stage of pronounced depression state in animals. Similar processes had place in brain dopaminergic systems. It is concluded that dynamic changes of brain monoaminergic activities accompany the development of anxious depression in animals. Various parameters of monoaminergic systems are differently changed depending on brain area, mediator system and stage of disorder.

Author information

Author/s: Avgustinovich, D F (DF); Alekseenko, O V (OV); Bakshtanovskaia, I V (IV); Koriakina, L A (LA); Lipina, T V (TV); Tenditnik, M V (MV); Bondar', N P (NP); Kovalenko, I L (IL); Kudriavtseva, N N (NN);

Journal and publication information

Publication Type: Comparative Study; English Abstract; Journal Article; Review

Journal: Uspekhi fiziologicheskikh nauk (Usp Fiziol Nauk), published in Russia. (Language: rus)

Reference: -2004 Oct-Dec; vol 35 (issue 4) : pp 19-40

Dates: Created 2004/12/02; Completed 2005/03/31; Revised 2006/11/15;

PMID: 15573884, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amygdala - metabolism Animals Brain - metabolism Depression - etiology; metabolism; physiopathology Disease Models, Animal Dopamine - deficiency; metabolism Hippocampus - metabolism Hydroxyindoleacetic Acid - metabolism Male

Male Mice Mice, Inbred C57BL Monoamine Oxidase - metabolism Nucleus Accumbens - metabolism Receptor, Serotonin, 5-HT1A - antagonists & inhibitors; metabolism Serotonin - deficiency; metabolism Serotonin Agents - administration & dosage Tryptophan Hydroxylase - metabolism

Associated Chemicals: Serotonin Agents (0) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (50-67-9) ; Dopamine (51-61-6) ; Hydroxyindoleacetic Acid (54-16-0) ; Tryptophan Hydroxylase (EC 1.14.16.4) ; Monoamine Oxidase (EC 1.4.3.4)

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