Research article summary (published 30 Oct 2004):

[The expression of platelet-derived growth factor (PDGF) receptor-beta and its correlation with extracellular matrix in hepatic tissue in hepatic fibrosis rats.]

Full Abstract

OBJECTIVE: To investigate the expression of PDGF receptor-beta and its correlation with extracellular matrix in hepatic tissue during hepatic fibrosis. METHODS: The model of hepatic fibrosis in rats was induced by carbon tetrachloride. PDGF receptor-beta subunit, collagen I, collagen III and a-SMA in hepatic tissues of these rats were examined using immunohistochemistry. The correlation between PDGF receptor-beta subunit and collagen I, III was analyzed using SAS software after the results of immunohistochemistry were semi-quantified. RESULTS: PDGF receptor-beta subunit and a-SMA were not detected in normal controls. Collagen I and III were distributed in the portal tracts and beneath the endothelia of the central veins and of the Disse spaces. Two weeks after CCl4 injection, the PDGF receptor-beta and a-SMA were detected, and the expression of collagen I and III increased. At the end of 4 and 6 weeks, the above four proteins were further increased. Two weeks after CCl4 injection, PDGF receptor-beta had no apparent correlation with collagen I and III. However, PDGF receptor-beta had a significant correlation with collagen I and III 2 weeks later, and the correlation coefficient was 0.74 and 0.60 respectively at 4 weeks, and 0.83 and 0.67 respectively at 6 weeks. PDGF receptor-beta had a significant correlation with a-SMA during the whole process of hepatic fibrosis and the correlation coefficient was 0.62, 0.69 and 0.81, respectively at the time of 2, 4 and 6 weeks after CCl4 injection. CONCLUSION: The PDGF receptor-beta was overexpressed during the process of hepatic fibrosis development, and it significantly correlated with collagen I and collagen III.

Author information

Author/s: Lu, Cui-hua (CH); Chen, Yue-xiang (YX); Zhang, Zhong-bing (ZB); Xie, Wei-fen (WF); Huang, Jie-fei (JF); Ni, Run-zhou (RZ); Guo, Ya-jun (YJ); Wei, Li-xin (LX); Jin, You-xin (YX);

Affiliation: Department of Gastroenterology, Affiliated Hospital of Nantong Medical University, Jiangsu Province, Nantong 226001, China.

Journal and publication information

Publication Type: English Abstract; Journal Article; Research Support, Non-U.S. Gov't

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi), published in China. (Language: chi)

Reference: 2004-Nov; vol 12 (issue 11) : pp 663-5

Dates: Created 2004/12/29; Completed 2006/10/20; Revised 2006/11/15;

PMID: 15623374, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Carbon Tetrachloride Carbon Tetrachloride Poisoning Collagen Type I - biosynthesis; genetics Collagen Type III - biosynthesis; genetics Extracellular Matrix - metabolism

Liver - metabolism Liver Cirrhosis, Experimental - chemically induced; metabolism Male Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta - biosynthesis; genetics

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Carbon Tetrachloride (56-23-5) ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.1.112)

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