[Drug allergies. Clinical aspects, pathophysiology and treatment of cutaneous manifestations]

(Arzneimittelallergien. Klinik, Pathophysiologie und Therapie kutaner Manifestationsformen.)

Full Abstract

Cutaneous adverse drug reactions (ADR) are common and encompass a broad clinical spectrum. Since the skin acts as a signaling organ for ADR, the dermatologist plays a key role in their diagnosis. Only a minor part of cutaneous ADR are due to underlying allergic mechanisms. Among these, delayed-type reactions such as maculopapular exanthems and immediate-type reactions such as urticaria and angioedema predominate. Risk factors for the development of cutaneous allergic ADR may be related to the patient (e.g. certain HLA-types), the drug (e.g. its reactivity), and underlying conditions (e.g. viral infections). Antibiotics, non-steroidal anti-inflammatory agents and anticonvulsive medications are most often reported to be causally related.

Author information

Author/s: Sachs, B (B); Merk, H F (HF);

Affiliation: Abteilung Pharmakovigilanz, Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn. b.sachs(-atsign-)bfarm.de

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt), published in Germany. (Language: ger)

Reference: 2005-Jan; vol 56 (issue 1) : pp 8-15

Dates: Created 2005/01/27; Completed 2005/09/22; Revised 2007/11/15;

PMID: 15645191, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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