Research article summary (published 29 Apr 2005):

Cortical GABAergic regulation of dopaminergic responses to psychological stress in the rat dorsolateral striatum.

Full Abstract

The present study was undertaken to examine the possible involvement of cortical gamma-aminobutyric acid (GABA) neuronal mechanisms in the regional differences of dopamine (DA) response to psychological stress: contextual fear conditioning (CFC) in the rat prefrontal cortex (PFC) and dorsolateral striatum (DLS). Rats that received five footshocks (shock intensity, 0.5 mA; shock duration, 2 sec) were subjected to CFC and dynamic changes in DA and GABA in both PFC and DLS were examined using dual-probe microdialysis. Extracellular levels of DA in the PFC were enhanced during exposure to CFC, whereas the levels in the DLS were not affected by this stimulus. Extracellular levels of GABA in the PFC, but not in the DLS, were markedly enhanced by CFC. Freezing behavior observed during exposure to CFC was attenuated by the GABA(A) receptor antagonist bicuculline (10(-3) M), which was perfused into the PFC. Intracortical application of bicuculline (10(-3) M) furthermore caused sustained increases in DA levels in the DLS by CFC. These data suggest that cortical GABA(A) receptors contribute to modulation of DA release in the DLS in response to CFC. Thus, the GABAergic neuronal system in the PFC appears to play a key role in the regional differences of the DAergic response to psychological stress. 2005 Wiley-Liss, Inc.

Author information

Author/s: Matsumoto, Machiko (M); Togashi, Hiroko (H); Kaku, Asako (A); Kanno, Manabu (M); Tahara, Kazue (K); Yoshioka, Mitsuhiro (M);

Affiliation: Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Synapse (New York, N.Y.) (Synapse), published in United States. (Language: eng)

Reference: 2005-May; vol 56 (issue 2) : pp 117-21

Dates: Created 2005/03/01; Completed 2005/06/06; Revised 2006/11/15;

PMID: 15729738, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance Animals Behavior, Animal Bicuculline - pharmacology Corpus Striatum - metabolism; radiation effects Dopamine - metabolism Dose-Response Relationship, Drug Electroshock - adverse effects Extracellular Space - drug effects; metabolism; radiation effects Freezing Reaction, Cataleptic - drug effects; physiology; radiation effects

Freezing Reaction, Cataleptic - drug effects; physiology; radiation effects GABA Antagonists - pharmacology Male Microdialysis - methods Prefrontal Cortex - drug effects; metabolism; radiation effects Rats Rats, Wistar Stress, Psychological - etiology; metabolism Time Factors gamma-Aminobutyric Acid - physiology

Associated Chemicals: GABA Antagonists (0) ; Bicuculline (485-49-4) ; Dopamine (51-61-6) ; gamma-Aminobutyric Acid (56-12-2)

Related articles

These are the highest related articles currently in the database:

• Glutamatergic control of dopamine release during stress in the rat prefrontal cortex. 30 Jul 1994
• Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142. 30 May 2002
• Blockade of tachykinin NK1 receptors attenuates stress-induced rise of extracellular noradrenaline and dopamine in the rat and gerbil medial prefrontal cortex. 29 Sep 2006
• Learned helplessness and in vivo hippocampal norepinephrine release. 30 Aug 1993
• Effects of partial dopamine loss in the medial prefrontal cortex on local baseline and stress-evoked extracellular dopamine concentrations. 30 Dec 1998
• Repeated cocaine and stress increase dopamine clearance in the rat medial prefrontal cortex. 29 Oct 1997
• GABAergic mediation of stress-induced secretion of corticosterone and oxytocin, but not prolactin, by the hypothalamic paraventricular nucleus. 21 Sep 2008
• GABA selectively controls the secretory activity of oxytocin neurons in the rat supraoptic nucleus. 30 Jan 2004
• Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex. 30 Mar 1993
• Stress-induced sensitization of dopamine and norepinephrine efflux in medial prefrontal cortex of the rat. 30 Jul 1994

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.