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| Research article summary (published 27 Feb 2005): |
The role of the prefrontal cortex in the maintenance of verbal working memory: an event-related FMRI analysis.
Full Abstract
Neuroimaging studies have been inconclusive in characterizing the role of the prefrontal cortex (PFC) for maintaining increasingly larger amounts of information in working memory (WM). To address this question, the authors collected event-related functional MRI data while participants performed an item-recognition task in which the number of to-be-remembered letters was parametrically modulated. During maintenance of information in WM, the dorsolateral and the ventrolateral PFC exhibited linearly increasing activation in response to increasing WM load. Prefrontal regions could not be distinguished from one another on the basis of load sensitivity, but the dorsolateral PFC had stronger functional connectivity with the parietal and motor cortex than the ventrolateral PFC. These results suggest an increasingly important role for the PFC in actively maintaining information as the amount of that information increases. ((c) 2005 APA, all rights reserved).
Author information
Author/s: Narayanan, Nandakumar S (NS); Prabhakaran, Vivek (V); Bunge, Silvia A (SA); Christoff, Kalina (K); Fine, Eric M (EM); Gabrieli, John D E (JD);
Affiliation: Department of Psychology, Stanford University, Stanford, CA, USA. kumar.narayanan(-atsign-)yale.edu
Grants: AG12995 (Agency:NIA NIH HHS) ; MH61426 (Agency:NIMH NIH HHS)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: Neuropsychology (Neuropsychology), published in United States. (Language: eng)
Reference: 2005-Mar; vol 19 (issue 2) : pp 223-32
Dates: Created 2005/03/16; Completed 2005/05/27; Revised 2007/11/14;
PMID: 15769206, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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