Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD.

Full Abstract

Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm(2), 25.0 cm(2), and 37.5 cm(2)). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH--even lower than in previous studies--yielded enhanced effects in combination with behavior modification. Copyright 2005 APA, all rights reserved.

Author information

Author/s: Pelham, William E (WE); Burrows-Maclean, Lisa (L); Gnagy, Elizabeth M (EM); Fabiano, Gregory A (GA); Coles, Erika K (EK); Tresco, Katy E (KE); Chacko, Anil (A); Wymbs, Brian T (BT); Wienke, Amber L (AL); Walker, Kathryn S (KS); Hoffman, Martin T (MT);

Affiliation: Department of Psychology, University at Buffalo, State University of New York, 14214, USA. pelham(-atsign-)buffalo.edu

Grants: AA11873 (Agency:NIAAA NIH HHS) ; DA12414 (Agency:NIDA NIH HHS) ; MH 53554 (Agency:NIMH NIH HHS) ; MH62946 (Agency:NIMH NIH HHS) ; NS39087 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Experimental and clinical psychopharmacology (Exp Clin Psychopharmacol), published in United States. (Language: eng)

Reference: 2005-May; vol 13 (issue 2) : pp 111-26

Dates: Created 2005/06/09; Completed 2005/09/08; Revised 2007/11/14;

PMID: 15943544, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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