Research article summary (published 30 Aug 2005):

Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats.

Full Abstract

Abnormalities in lipid profile are one of the most common complications in diabetes mellitus, which is found in about 40% of diabetics. In the present study, anti-hyperlipidemic efficacy of Eugenia jambolana seed kernel (EJs-kernel) was evaluated in streptozotocin (STZ)-induced diabetic rats and the efficacy was compared with standard hypoglycemic drug, glibenclamide. The effect of oral administration of ethanolic extract of EJs-kernel (100 mg/kg body weight) was examined on the levels of cholesterol, phospholipids, triglycerides and free fatty acids in the plasma, liver and kidney tissues of STZ (55 mg/kg body weight)-induced diabetic rats. The plasma lipoproteins and tissues fatty acid composition were also monitored. STZ-induced diabetic rats, showed significant increase in the levels of cholesterol, phospholipids, triglycerides and free fatty acids which were considerably restored to near normal in EJs-kernel or glibenclamide treated animals. The plasma lipoproteins (HDL, LDL, VLDL-cholesterol) and fatty acid composition were altered in STZ-induced diabetic rats and these levels were also reverted back to near normalcy by EJs-kernel or glibenclamide treatment. It may be concluded that, EJs-kernel possesses hypolipidemic effect, which may be due to the presence of flavonoids, saponins, glycosides and triterpenoids in the extract. The hypolipidemic effect mediated by EJs-kernel may also be anticipated to have biological significance and provide a scientific rationale for the use of EJs-kernel as an anti-diabetic plant.

Author information

Author/s: Ravi, Kasiappan (K); Rajasekaran, Subbaih (S); Subramanian, Sorimuthu (S);

Affiliation: Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.

Journal and publication information

Publication Type: Journal Article

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol), published in England. (Language: eng)

Reference: 2005-Sep; vol 43 (issue 9) : pp 1433-9

Dates: Created 2005/07/01; Completed 2005/09/27; Revised 2006/03/13;

PMID: 15964674, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antilipemic Agents - pharmacology Cholesterol - blood Diabetes Mellitus, Experimental - blood Eugenia - chemistry Fatty Acids - blood Fruit - chemistry Glyburide - pharmacology Hypoglycemic Agents - pharmacology

Lipids - blood Lipoproteins - blood Male Phospholipids - blood Plant Extracts - pharmacology Rats Rats, Wistar Seeds - chemistry Triglycerides - blood

Associated Chemicals: Antilipemic Agents (0) ; Fatty Acids (0) ; Hypoglycemic Agents (0) ; Lipids (0) ; Lipoproteins (0) ; Phospholipids (0) ; Plant Extracts (0) ; Triglycerides (0) ; Glyburide (10238-21-8) ; Cholesterol (57-88-5)

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