Research article summary (published 29 Jun 2005):

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder.

Full Abstract

PURPOSE: The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention. SUBJECTS AND METHODS: Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design. RESULTS: Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively. DISCUSSION AND CONCLUSION: In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Author information

Author/s: Lijffijt, Marijn (M); Kenemans, J Leon (JL); ter Wal, Annemiek (A); Quik, Elise H (EH); Kemner, C (C); Westenberg, Herman (H); Verbaten, Marinus N (MN); van Engeland, Herman (H);

Affiliation: Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. malijffi(-atsign-)utmb.edu

Journal and publication information

Publication Type: Clinical Trial; Journal Article

Journal: European psychiatry : the journal of the Association of European Psychiatrists (Eur Psychiatry), published in France. (Language: eng)

Reference: 2006-Dec; vol 21 (issue 8) : pp 544-7

Dates: Created 2006/12/12; Completed 2007/02/23;

PMID: 15994064, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Attention - drug effects Attention Deficit Disorder with Hyperactivity - blood; drug therapy; psychology Central Nervous System Stimulants - pharmacology Child Child Behavior - drug effects; psychology Dopamine - blood Dose-Response Relationship, Drug Female

Female Humans Inhibition (Psychology) Internal-External Control Male Methylphenidate - pharmacology Norepinephrine - blood Reaction Time - drug effects Task Performance and Analysis

Associated Chemicals: Central Nervous System Stimulants (0) ; Methylphenidate (113-45-1) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6)

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