[Effect of perindopril on renal interstitial fibrosis of hypertension in rats]

Full Abstract

OBJECTIVE: To explore the effect of perindopril on renal interstitial fibrosis of spontaneously hypertensive rats and on the expression of transforming growth factor-beta1. METHODS: Spontaneously hypertensive rats at the age of 9 weeks were randomly assigned to 2 groups: Spontaneously hypertensive rats (SHR, vehicle once daily, n = 10) and Treament-SHR (T-SHR, perindopril, 4 mg/(kg x d), per day PO, n = 10). Wistar-Kyoto rats (WKY, n = 7) were served as controls. After 10 weeks of treatment, the serum concentration of TGF-beta1, collagen type I, III and TGF-beta1 in the renal interstitum and renal mRNA levels of TGF-beta1 were detected. RESULTS: There were no significant differences in the serum TGF-beta1 levels among the 3 groups (P > 0.05). Immunohistochemical studies revealed a significant interstitial accumulation of collagens I, III and TGF-beta1 in SHR compared with those in WKY (P < 0.01 or P < 0.05). These changes in SHR were significantly ameliorated by the administration of perindopril (P < 0.01 or P < 0.05). In SHR, renal TGF-beta1 mRNA expression was increased significantly compared with that in WKY (P < 0.01), but perindopril decreased it to the normal levels of WKY (P > 0.05). The increased expression of TGF-beta1 was blocked by perindopril. The expressions of collagens I and III in renal interstitum significantly correlated with the accumulation of TGF-beta1 in the renal (r = 0. 734, r = 0.762, respectively; P < 0.01). CONCLUSION: The tubulointerstitial fibrosis of spontaneously hypertensive rats is mediated by an increased level of TGF-beta1 in the renal tissue, and perindopril may decrease the expression of TGF-beta1 to ameliorate the tubulointerstitial fibrosis.

Author information

Author/s: Xu, Hui (H); Tao, Li-Jian (LJ); Sun, Ming (M);

Affiliation: Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban), published in China. (Language: chi)

Reference: 2004-Feb; vol 29 (issue 1) : pp 61-4

Dates: Created 2005/09/02; Completed 2006/09/19; Revised 2006/11/15;

PMID: 16137008, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Angiotensin-Converting Enzyme Inhibitors - pharmacology; therapeutic use
Animals
Collagen Type I - biosynthesis; genetics
Collagen Type III - biosynthesis; genetics
Female
Hypertension - complications; drug therapy
Kidney - metabolism
Male

Nephrosclerosis - drug therapy; metabolism
Perindopril - pharmacology; therapeutic use
RNA, Messenger - biosynthesis; genetics
Random Allocation
Rats
Rats, Inbred SHR
Transforming Growth Factor beta - biosynthesis; genetics
Transforming Growth Factor beta1

Associated Chemicals: Angiotensin-Converting Enzyme Inhibitors (0) ; Collagen Type I (0) ; Collagen Type III (0) ; RNA, Messenger (0) ; Tgfb1 protein, rat (0) ; Transforming Growth Factor beta (0) ; Transforming Growth Factor beta1 (0) ; Perindopril (82834-16-0)

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