Research article summary (published 29 Sep 2005):

High rate of joint capsule matrix turnover in chronic human elbow contractures.

Full Abstract

The joint capsule is a key component in posttraumatic joint contractures. The capsule is described as thickened, but little data exist supporting the observation. Our hypotheses were that mRNA levels of (1) collagen; (2) decorin and biglycan; (3) matrix metalloproteinases; and (4) tissue inhibitors of matrix metalloproteinases were significantly elevated in anterior joint capsules obtained from 11 patients having surgery for posttraumatic contractures when compared with nine elbows, from organ donors, that were free of contractures. Reverse transcription-polymerase chain reaction was used to evaluate mRNA expression normalized to a housekeeping gene, glyceraldehyde-3-phosphate dehydrogenase. In the joint capsules of the patients with elbow contractures, relative mRNA levels were increased for: collagen Types I, III, and V (1.5-2.5 times); biglycan (1.5 times); and matrix metalloproteinases-1, -2, -9, -13, and -15 (1.6-3.9 times). In contrast, expression of tissue inhibitors of matrix metalloproteinases-1, -2, and -4 were decreased (1/3-3/4 times) in the capsules of patients with contractures. There was no difference between the groups in relative mRNA expression for decorin, matrix metalloproteinases-8, -14 and -16, and tissue inhibitor of matrix metalloproteinase-3. The results indicate that joint capsule matrix molecule mRNA levels are altered in the chronic stages of posttraumatic elbow contractures in humans, potentially creating an environment with high matrix turnover rates.

Author information

Author/s: Hildebrand, Kevin A (KA); Zhang, Mei (M); Hart, David A (DA);

Affiliation: McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada. hildebrk(-atsign-)ucalgary.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Clinical orthopaedics and related research (Clin Orthop Relat Res), published in United States. (Language: eng)

Reference: 2005-Oct; vol 439 (issue ) : pp 228-34

Dates: Created 2005/10/05; Completed 2005/12/15; Revised 2006/11/15;

PMID: 16205164, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Chronic Disease Collagen Type I - genetics Collagen Type III - genetics Collagen Type V - genetics Contracture - pathology; physiopathology Elbow Joint - pathology; physiopathology Extracellular Matrix Proteins - genetics Female

Female Gene Expression Humans Joint Capsule - pathology; physiopathology Male Matrix Metalloproteinases - genetics Middle Aged Proteoglycans - genetics RNA, Messenger - analysis Tissue Inhibitor of Metalloproteinases - genetics

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Collagen Type V (0) ; Extracellular Matrix Proteins (0) ; Proteoglycans (0) ; RNA, Messenger (0) ; Tissue Inhibitor of Metalloproteinases (0) ; biglycan (123939-84-4) ; Matrix Metalloproteinases (EC 3.4.24.-)

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