One-year follow-up of mild traumatic brain injury: post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase.

Full Abstract

OBJECTIVE: To investigate, in patients with mild traumatic brain injury, serum concentrations of S-100B and neurone-specific enolase in acute phase and post-concussion symptoms, disabilities and life satisfaction 1 year after the trauma. DESIGN: Prospective study. PATIENTS: Eighty-eight patients (age range 18-87 years). METHODS: Blood samples were taken on admission and about 7 hours later. At follow-up 15 +/- 4 months later, the patients filled in questionnaires about symptoms (Rivermead Post Concussion Symptoms), disability (Rivermead Head Injury Follow-up) and life satisfaction (LiSat-11). RESULTS: Concentrations of S-100B and neurone-specific enolase were regularly increased in the first blood sample. Of the 69 patients participating in the follow-up, 45% reported post-concussion symptom, 48% exhibited disability and 55% were satisfied with "life as a whole". In comparison with the "sick-leave" situation on admission to hospital, 3 patients were on sick-leave at the time of follow-up because of the head trauma. Stepwise forward logistic regression analysis revealed a statistically significant association (p<0.05) between disability and S-100B and dizziness. CONCLUSION: In spite of frequent persistent symptoms, disabilities and low levels of life satisfaction, the sick-leave frequency was low at follow-up. The association between S-100B and disability supports the notion that long-term consequences of a mild brain injury may partly be a result of brain tissue injury.

Author information

Author/s: Stålnacke, Britt-Marie (BM); Björnstig, Ulf (U); Karlsson, Kurt (K); Sojka, Peter (P);

Affiliation: Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Umeå University Hospital, Umeå, Sweden. brittmarie.stalnacke(-atsign-)rehabmed.umu.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine (J Rehabil Med), published in Sweden. (Language: eng)

Reference: 2005-Sep; vol 37 (issue 5) : pp 300-5

Dates: Created 2005/10/06; Completed 2005/10/12; Revised 2006/11/15;

PMID: 16208863, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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