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| Research article summary (published 18 Oct 2005): |
A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.
Full Abstract
The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila. Here we identify mutants (groom-of-PDF; gop) that display phase-advanced evening activity and poor free-running rhythmicity, phenocopying pdf mutants. In gop mutants, a spontaneous retrotransposon disrupts a coding exon of a G protein-coupled receptor, CG13758. Disruption of the receptor is accompanied by phase-advanced oscillations of the core clock protein PERIOD. Moreover, effects on circadian timing induced by perturbation of PDF neurons require gop. Yet PDF oscillations themselves remain robust in gop mutants, suggesting that GOP acts downstream of PDF. gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila.
Author information
Author/s: Lear, Bridget C (BC); Merrill, C Elaine (CE); Lin, Jui-Ming (JM); Schroeder, Analyne (A); Zhang, Luoying (L); Allada, Ravi (R);
Affiliation: Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2005-Oct; vol 48 (issue 2) : pp 221-7
Dates: Created 2005/10/24; Completed 2006/01/20; Revised 2006/11/15;
PMID: 16242403, status: MEDLINE (last retrieved date: 2/18/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Neuron. 2005 Oct 20;48(2):161-3. (PMID: 16242393)
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Associated Chemicals: Drosophila Proteins (0) ; Mutant Proteins (0) ; Neuropeptides (0) ; Receptors, G-Protein-Coupled (0) ; groom-of-PDF protein, Drosophila (0) ; pdf protein, Drosophila (0)Related articles
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