Research article summary (published 29 Sep 2005):

Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves.

Full Abstract

This study examined the antinociceptive effect of Bauhinia microstachya (Leguminosae), a native plant widely distributed in the South of Brazil, in several chemical and mechanical models of pain. The methanolic extract (ME) from B. microstachya (3--30 mg kg(-1), i.p.) and the isolated compound quercitrin (1--10 mg kg(-1), i.p.), given 30 min earlier, produced a dose-dependent inhibition of acetic-acid-induced visceral pain in mice, with a mean ID50 value (dose necessary to reduce the nociceptive response by 50% relative to the control value) of 7.9 and 2.4 mg kg(-1), respectively. The ME of B. microstachya (3--100 mg kg(-1), i.p., 30 min earlier) also caused a dose-dependent inhibition of capsaicin-induced pain, with a mean ID50 value of 18.8 mg kg(-1). Moreover, the ME (3--100 mg kg(-1), i.p., 30 min earlier) produced marked inhibition of both phases of formalin-induced pain, with mean ID50 values for the neurogenic and the inflammatory phases of 30.3 and 17.2 mg kg(-1), respectively. In addition, the ME of B. microstachya (3--300 mg kg(-1), i.p., 30 min earlier) inhibited, in a graded manner, the hyperalgesia induced by bradykinin (3.2 microg/paw), substance P (13.5 microg/paw), carrageenan (300 microg/paw), capsaicin (100 microg/paw) and adrenaline (100 ng/paw) in the rat paw, with mean ID50 values of 20.5, 17.9, 101.8, 54.2 and 99.7 mg kg(-1), respectively. Taken together, these data demonstrate that ME of B. microstachya elicited a pronounced antinociceptive action against several chemical and mechanical models of pain in mice and rats. The precise mechanism responsible for the antinociceptive effect of the extract still remains unclear, but seems to be partly related to modulation of the release or action of pro-inflammatory mediators involved in the models of pain used. Finally, the flavonoid quercitrin isolated from this plant appears to contribute for the antinociceptive property of the methanolic extract.

Author information

Author/s: Gadotti, Vinícius M (VM); Schmeling, Leonardo O (LO); Machado, Cláudia (C); Liz, Fernanda H (FH); Filho, Valdir Cechinel (VC); Meyre-Silva, Christiane (C); Santos, Adair R S (AR);

Affiliation: Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis 88040-900, SC, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol), published in England. (Language: eng)

Reference: 2005-Oct; vol 57 (issue 10) : pp 1345-51

Dates: Created 2005/11/01; Completed 2006/04/18; Revised 2006/11/15;

PMID: 16259764, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Abdominal Muscles - drug effects; physiopathology Acetic Acid Analgesics - chemistry; isolation & purification; pharmacology Animals Bauhinia - chemistry Carrageenan Constriction, Pathologic - chemically induced; physiopathology Dose-Response Relationship, Drug Formaldehyde Hyperalgesia - chemically induced; prevention & control

Hyperalgesia - chemically induced; prevention & control Injections, Intraperitoneal Mice Pain - chemically induced; prevention & control Pain Measurement - methods Plant Extracts - chemistry; isolation & purification; pharmacology Plant Leaves - chemistry Quercetin - analogs & derivatives; chemistry; isolation & purification; pharmacology Rats Rats, Wistar

Associated Chemicals: Analgesics (0) ; Plant Extracts (0) ; Quercetin (117-39-5) ; Formaldehyde (50-00-0) ; quercitrin (522-12-3) ; Acetic Acid (64-19-7) ; Carrageenan (9000-07-1)

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