Research article summary (published 30 Oct 2005):

Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia.

Full Abstract

A new acetophenone derivative, melicopone, along with twenty-nine known compounds has been isolated from the root wood of Melicope semecarpifolia. The structure of this new compound was determined using spectral analyses. The compound oxynitidine isolated in this study adds the Melicope genus to the benzo[c]phenanthridine-containing members chemotaxonomically. Three isolates were cytotoxic in P-388 and HT-29 cell lines, and anti-platelet aggregation activities were shown for 10 known compounds.

Author information

Author/s: Chou, Hsueh-Chun (HC); Chen, Jih-Jung (JJ); Duh, Chang-Yih (CY); Huang, Tur-Fu (TF); Chen, Ih-Sheng (IS);

Affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan, Republic of China.

Journal and publication information

Publication Type: Journal Article

Journal: Planta medica (Planta Med), published in Germany. (Language: eng)

Reference: 2005-Nov; vol 71 (issue 11) : pp 1078-81

Dates: Created 2005/12/01; Completed 2006/02/03;

PMID: 16320216, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetophenones - chemistry; isolation & purification; pharmacology Antineoplastic Agents - chemistry; isolation & purification; pharmacology Benzaldehydes - isolation & purification; pharmacology Benzoic Acid - isolation & purification; pharmacology Coumarins - isolation & purification; pharmacology Flavonoids - isolation & purification; pharmacology HT29 Cells Humans

Humans Lignans - isolation & purification; pharmacology Molecular Structure Plant Extracts - chemistry; pharmacology Plant Roots - chemistry Platelet Aggregation Inhibitors - chemistry; isolation & purification; pharmacology Quinolines - isolation & purification; pharmacology Rutaceae - chemistry

Associated Chemicals: Acetophenones (0) ; Antineoplastic Agents (0) ; Benzaldehydes (0) ; Coumarins (0) ; Flavonoids (0) ; Lignans (0) ; Plant Extracts (0) ; Platelet Aggregation Inhibitors (0) ; Quinolines (0) ; ayanin (0) ; melicopone (0) ; Benzoic Acid (65-85-0)

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