Research article summary (published 30 Dec 2004):

Antioxidant and antimycobacterial activities of Tabernaemontana catharinensis extracts obtained by supercritical CO2 + cosolvent.

Full Abstract

In the present work the antioxidant and antimycobacterial activities were determined for extracts from Tabernaemontana catharinensis. The extracts' global yields were obtained using supercritical CO2 plus cosolvent. The cosolvents ethanol, isopropyl alcohol, methanol, and water and their mixtures were used. The extracts were fractionated and analyzed by thin-layer chromatography and gas chromatography/flame ionization detection. The antimycobacterial activity was measured against Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium kansasii. The antioxidant activity was determined by the coupled reaction of beta-carotene and limonene acid. The average global yield was approximately constant (2.4 +/- 0.1%) for the alcoholic cosolvents and significantly larger (15 +/- 1%) for the cosolvent water and its alcoholic mixtures. The content of alkaloids in the extracts was strongly affected by the cosolvent. The antioxidant activity of the extracts ranged from 53% to 95%. The highest antimycobacterial activity was detected in the alkaloidal fraction (minimum inhibitory concentration = 128 microg/mL), while the lowest was verified in the aqueous fraction (minimum inhibitory concentration >512 microg/mL).

Author information

Author/s: Pereira, Camila G (CG); Leal, Patrícia F (PF); Sato, Daisy N (DN); Meireles, M Angela A (MA);

Affiliation: Laboratory of Supercritical Technology: Extraction, Fractionation and Identification of Vegetable Extracts, Department of Food Engineering, College of Food Engineering, State University of Campinas, Campinas, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of medicinal food (J Med Food), published in United States. (Language: eng)

Reference: 2005-; vol 8 (issue 4) : pp 533-8

Dates: Created 2005/12/28; Completed 2006/05/22; Revised 2006/11/15;

PMID: 16379568, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Anti-Bacterial Agents - pharmacology Antioxidants - pharmacology Carbon Dioxide Chromatography, Supercritical Fluid Cyclohexenes Mycobacterium avium - drug effects Mycobacterium kansasii - drug effects

Mycobacterium kansasii - drug effects Mycobacterium tuberculosis - drug effects Plant Extracts - pharmacology Solvents Tabernaemontana - chemistry Terpenes - pharmacology beta Carotene - pharmacology

Associated Chemicals: Anti-Bacterial Agents (0) ; Antioxidants (0) ; Cyclohexenes (0) ; Plant Extracts (0) ; Solvents (0) ; Terpenes (0) ; Carbon Dioxide (124-38-9) ; limonene (138-86-3) ; beta Carotene (7235-40-7)

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