Research article summary (published 30 Jan 2006):

The tumour necrosis factor (TNF)-alpha-308GA promoter polymorphism is related to prenatal growth and postnatal insulin resistance.

Full Abstract

OBJECTIVE: Variation in the tumour necrosis factor gene, (TNF) has been associated with insulin resistance traits. We questioned whether the TNF-308G/A polymorphism is associated with birthweight and insulin resistance in children born small for gestational age (SGA), a patient population known to be at risk for insulin resistance. DESIGN: A cross-sectional, hospital-based study assessing insulin sensitivity in SGA children. PATIENTS: One hundred and ninety-eight school-age children born either SGA (n=90, age 7.4+/- 4.5 years) or appropriate for gestational age (AGA, n=108, age 8.7+/- 4.0 years). MEASUREMENTS: All children were genotyped for the TNF-308G/A polymorphism; a biochemical profile was also performed in prepubertal SGA (n=58) and AGA (n=57) subjects. RESULTS: Genotype frequencies for the TNF-308G/A single nucleotide polymorphisms (SNPs) (GG and GA/AA) differed between SGA and AGA children (86%vs. 72% and 14%vs. 28%, respectively; P=0.025). The GG genotype was associated with lower birthweight and birth length (2747.0+/- 23.3 g vs. 2851.0+/- 45.7 g, P=0.045, and 47.0+/- 0.2 cm vs. 48.2+/- 0.4 cm, P=0.011, respectively) and, in AGA but not in SGA children, with higher systolic blood pressure [103.3 (95% confidence interval (CI) 96.4-110.2) mmHg vs. 92.8 (84.9-100.7) mmHg; P=0.028], higher blood glucose [4.8 (4.7-5.0) mmol/l vs. 4.5 (4.3-4.8) mmol/l; P=0.042] and higher homeostasis model assessment for insulin resistance (HOMA-IR) index [1.4 (1.1-1.7) vs. 0.9 (0.4-1.3); P=0.005]. In multivariate analysis, the TNF-308GG genotype was an independent predictor of HOMA-IR during childhood, explaining 8% of its variance. CONCLUSION: SGA children show increased frequency of the TNF-308G allele, an allele that is associated with prenatal growth and with postnatal insulin resistance. The TNF-308G/A polymorphism may have implications in the growth and metabolic abnormalities that characterise SGA children.

Author information

Author/s: Casano-Sancho, Paula (P); López-Bermejo, Abel (A); Fernández-Real, José Manuel (JM); Monrós, Eugènia (E); Valls, Carme (C); Rodríguez-González, Francesc-Xavier (FX); Ricart, Wifredo (W); Ibáñez, Lourdes (L);

Affiliation: Paediatric Endocrinology, Sant Joan de Déu Children's Hospital, Barcelona, Spain.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Clinical endocrinology (Clin Endocrinol (Oxf)), published in England. (Language: eng)

Reference: 2006-Feb; vol 64 (issue 2) : pp 129-35

Dates: Created 2006/01/24; Completed 2006/06/05; Revised 2008/11/21;

PMID: 16430709, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Birth Weight - genetics Blood Glucose - analysis Blood Pressure - genetics Body Size - physiology Child Cross-Sectional Studies Female Fetal Development - genetics Gene Frequency - genetics Genotype

Humans Infant, Newborn Infant, Small for Gestational Age Insulin - blood Insulin Resistance - genetics Male Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Receptors, Tumor Necrosis Factor, Type II - blood Tumor Necrosis Factor-alpha - genetics

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Blood Glucose (0) ; Receptors, Tumor Necrosis Factor, Type II (0) ; Tumor Necrosis Factor-alpha (0) ; Insulin (11061-68-0)

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