Antibacterial activity of components from Lomatium californicum.

Full Abstract

The isolation, characterization and bioactivity testing of compounds from Lomatium californicum (Nutt.) are described. Ethyl acetate and hexane extracts of the roots of L. californicum were subjected to vacuum liquid chromatography (VLC), flash column chromatography (FCC) and separation by normal- and reverse-phase high-performance liquid chromatography (HPLC). Six compounds were isolated successfully and characterized by 1D and 2D nuclear magnetic resonance (NMR) experimentation. The bioactivity of the known compounds (+)-falcarindiol, coniferyl ferulate, ferulic acid and (Z)-ligustilide were confirmed against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. The known compounds senkyunolide I and trans-neocnidilide were also isolated but in too small a quantity for similar testing. Copyright 2006 John Wiley & Sons, Ltd.

Author information

Author/s: Chou, Shen-Chieh (SC); Everngam, Molly C (MC); Sturtz, George (G); Beck, John J (JJ);

Affiliation: Department of Chemistry, Sweet Briar College, Sweet Briar, VA 24595, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)

Reference: 2006-Feb; vol 20 (issue 2) : pp 153-6

Dates: Created 2006/02/07; Completed 2006/04/17; Revised 2006/11/15;

PMID: 16444670, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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