Research article summary (published 6 Feb 2006):

Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm.

Full Abstract

We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin(SN)Z(+) in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions; (2) a low-molecular weight isoform of muscle-specific receptor tyrosine kinase in human and mouse sperm localized in the flagellar mid-piece of human sperm.

Author information

Author/s: Kumar, Priyadarsini (P); Ferns, Michael J (MJ); Meizel, Stanley (S);

Affiliation: Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA. pkumar(-atsign-)ucdavis.edu

Grants: 5T32 HD 007131 (Agency:NICHD NIH HHS) ; HD 33368 (Agency:NICHD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), published in United States. (Language: eng)

Reference: 2006-Apr; vol 342 (issue 2) : pp 522-8

Dates: Created 2006/02/28; Completed 2006/04/28; Revised 2007/11/14;

PMID: 16487930, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

ErratumIn: Biochem Biophys Res Commun. 2006 May 26;344(1):453.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Acrosome - enzymology; metabolism Agrin - isolation & purification; metabolism Animals Blotting, Western Humans Male Mice Mice, Inbred C57BL

Molecular Weight Protein Isoforms - isolation & purification; metabolism Receptor Protein-Tyrosine Kinases - isolation & purification; metabolism Receptors, Cholinergic - isolation & purification; metabolism Reverse Transcriptase Polymerase Chain Reaction Sperm Tail - enzymology; metabolism Spermatozoa - enzymology; metabolism Testis - enzymology; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Agrin (0) ; Protein Isoforms (0) ; Receptors, Cholinergic (0) ; Receptor Protein-Tyrosine Kinases (EC 2.7.1.112) ; MUSK protein, human (EC 2.7.10.1)

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