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| Research article summary (published 27 Feb 2006): |
Antioxidants from Rabdosia japonica.
Full Abstract
The antioxidant activities of phenolic compounds: pedalitin, quercetin, rutin, isoquercitrin, and rosmarinic acid, isolated from the dried leaves of Rabdosia japonica Hara (Labiatae) were elucidated. All the phenolics tested exhibited superoxide scavenging activity and an inhibitory effect on xanthine oxidase (EC 1.1.3.22), and pedalitin showed the most potent antioxidant activity. Pedalitin prevents the generation of superoxide radicals in part by inhibiting xanthine oxidase competitively. Both pedalitin and quercetin inhibited uric acid formation by xanthine oxidase, and the inhibition kinetics analysed by Lineweaver-Burk plots found both flavonoids to be competitive inhibitors. On the other hand, isoquercitrin, rutin and rosmarinic acid were effective in scavenging superoxide radicals generated by the xanthine-xanthine oxidase system without inhibiting the enzyme. Copyright 2006 John Wiley & Sons, Ltd.
Author information
Author/s: Masuoka, Noriyoshi (N); Isobe, Takahiko (T); Kubo, Isao (I);
Affiliation: Department of Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan.
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)
Reference: 2006-Mar; vol 20 (issue 3) : pp 206-13
Dates: Created 2006/04/17; Completed 2006/06/09; Revised 2007/11/15;
PMID: 16521110, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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