Research article summary (published 30 Dec 1990):

Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory.

Full Abstract

Previous research has demonstrated that low doses of anxiogenic central benzodiazepine receptor (CBR) ligands, the beta-carbolines, improve performance in various learning and memory tests in animals if administered prior to training. The present experiments compared the effect of a beta-carboline (FG 7142) with that of a pharmacologically distinct anxiogenic compound, a peripheral benzodiazepine receptor (PBR) ligand, 4'-chlorodiazepam (Ro5-4864), in two tests of learning and memory in rats. As expected, FG 7142 significantly improved performance in a passive avoidance test. Ro5-4864 was without effect. In a shuttlebox escape test, Ro5-4864 significantly impaired performance while FG 7142 had no effect. The effect of Ro5-4864 was antagonized by the specific peripheral benzodiazepine receptor antagonist, PK 11195. These results indicate that the differential impact of CBR and PBR anxiogenic ligands on performance in aversively-motivated learning tests may be a reflection of their distinct pharmacologies.

Author information

Author/s: Holmes, P V (PV); Drugan, R C (RC);

Affiliation: Department of Psychology, Brown University, Providence, RI 02912.

Grants: 2SO 7RR0708524 (Agency:NCRR NIH HHS) ; R03 MH 44034-01A (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in GERMANY. (Language: eng)

Reference: 1991-; vol 104 (issue 2) : pp 249-54

Dates: Created 1991/09/26; Completed 1991/09/26; Revised 2007/11/14;

PMID: 1652145, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Anxiety - psychology Avoidance Learning - drug effects Benzodiazepinones - pharmacology Carbolines - pharmacology Conditioning, Operant - drug effects Isoquinolines - pharmacology Learning - drug effects

Learning - drug effects Ligands Male Memory - drug effects Rats Rats, Inbred Strains Reaction Time - drug effects Receptors, GABA-A - drug effects

Associated Chemicals: Benzodiazepinones (0) ; Carbolines (0) ; Isoquinolines (0) ; Ligands (0) ; Receptors, GABA-A (0) ; 4'-chlorodiazepam (14439-61-3) ; FG 7142 (78538-74-6) ; PK 11195 (85340-56-3)

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