Oligonucleotide microarray expression profiling: human skeletal muscle phenotype and aerobic exercise training.

Full Abstract

Regular aerobic exercise reduces risk of cardiovascular disease far more effectively than any pharmaceutical agent. The precise mechanisms contributing to these health benefits are unknown. Currently, much of our knowledge regarding the molecular regulators of skeletal muscle phenotype remodeling in response to muscle activity is derived from rodent models. Over the past five years large scale gene analysis has emerged as a promising research strategy for studying complex processes in human tissue. This review will principally discuss the application of large scale gene expression profiling to study the molecular responses to longitudinal aerobic exercise training studies in humans. The focus is largely on the Affymetrix technology platform, as this can be most easily compared, in a quantitative manner, across laboratories. Indeed, there are compelling reasons to adopt a common standard to obtain maximum synergy across complex, expensive and invasive human studies. Direct comparisons between array data sets can be made, and these should be considered novel 'experiments', often providing great insight into disease mechanisms. Weaknesses in existing human studies are identified and future objectives are discussed.

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Author information

Author/s: Timmons, James A (JA); Sundberg, Carl Johan (CJ);

Affiliation: Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden. Jamie.Timmons(-atsign-)gmail.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: IUBMB life (IUBMB Life), published in England. (Language: eng)

Reference: 2006-Jan; vol 58 (issue 1) : pp 15-24

Dates: Created 2006/03/16; Completed 2006/05/17; Revised 2006/11/15;

PMID: 16540428, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

ErratumIn: IUBMB Life. 2006 Feb;58(2):117.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Humans
Muscle, Skeletal - metabolism
Oligonucleotide Array Sequence Analysis

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