Research article summary (published 31 Mar 2006):

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.

Full Abstract

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.

Author information

Author/s: Plant, Karen (K); Pelkey, Kenneth A (KA); Bortolotto, Zuner A (ZA); Morita, Daiju (D); Terashima, Akira (A); McBain, Chris J (CJ); Collingridge, Graham L (GL); Isaac, John T R (JT);

Affiliation: MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK.

Grants: (Agency:Wellcome Trust)

Journal and publication information

Publication Type: Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal: Nature neuroscience (Nat Neurosci), published in United States. (Language: eng)

Reference: 2006-May; vol 9 (issue 5) : pp 602-4

Dates: Created 2006/04/26; Completed 2006/08/04; Revised 2007/08/13;

PMID: 16582904, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Nat Neurosci. 2006 May;9(5):593-4. (PMID: 16639403)

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Animals, Newborn Calcium - metabolism Dose-Response Relationship, Radiation Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects; physiology; radiation effects Hippocampus - cytology Long-Term Potentiation - drug effects; physiology; radiation effects

Mice Nicotinic Antagonists - pharmacology Patch-Clamp Techniques - methods Polyamines - pharmacology Pyramidal Cells - drug effects; physiology; radiation effects Rats Receptors, AMPA - chemistry; deficiency; physiology Time Factors

Associated Chemicals: Nicotinic Antagonists (0) ; Polyamines (0) ; Receptors, AMPA (0) ; glutamate receptor ionotropic, AMPA 2 (0) ; Calcium (7440-70-2) ; delta-philanthotoxin (77108-00-0)

Related articles

These are the highest related articles currently in the database:

• Asynchronic transmission in the CA3-CA1 hippocampal synapses in the neurological mutant taiep rat. 30 Dec 2006
• AMPA receptor modulators have different impact on hippocampal pyramidal cells and interneurons. 30 Dec 2004
• Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses. 29 Jun 2004
• Spine expansion and stabilization associated with long-term potentiation. 26 May 2008
• Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. 27 Feb 2007
• Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. 29 Oct 2007
• Polyamines modulate AMPA receptor-dependent synaptic responses in immature layer v pyramidal neurons. 29 Nov 2004
• Contribution of AMPA and NMDA receptors to early and late phases of LTP in hippocampal slices. 3 May 2006
• Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats. 21 Sep 2005
• Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus. 2 Apr 2007

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.