Research article summary (published 29 Apr 2006):

Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation.

Full Abstract

Stable gastric pentadecapeptide BPC 157 (BPC 157, as an antiulcer agent in clinical trials for inflammatory bowel disease; PLD-116, PL 14736, Pliva, no toxicity reported) alone (without carrier) ameliorates healing of tendon and bone, respectively, as well as other tissues. Thereby, we focus on Achilles tendon-to-bone healing: tendon to bone could not be healed spontaneously, but it was recovered by this peptide. After the rat's Achilles tendon was sharply transected from calcaneal bone, agents [BPC 157 (10 microg, 10 ng, 10 pg), 6alpha-methylprednisolone (1 mg), 0.9% NaCl (5 mL)] were given alone or in combination [/kg body weight (b.w.) intraperitoneally, once time daily, first 30-min after surgery, last 24 h before analysis]. Tested at days 1, 4, 7, 10, 14, and 21 after Achilles detachment, BPC 157 improves healing functionally [Achilles functional index (AFI) values substantially increased], biomechanically (load to failure, stiffness, and Young elasticity modulus significantly increased), macro/microscopically, immunohistochemistry (better organization of collagen fibers, and advanced vascular appearance, more collagen type I). 6alpha-Methylprednisolone consistently aggravates the healing, while BPC 157 substantially reduces 6alpha-methylprednisolone healing aggravation. Thus, direct tendon-to-bone healing using stabile nontoxic peptide BPC 157 without a carrier might successfully exchange the present reconstructive surgical methods. Copyright 2006 Orthopaedic Research Society.

Author information

Author/s: Krivic, Andrija (A); Anic, Tomislav (T); Seiwerth, Sven (S); Huljev, Dubravko (D); Sikiric, Predrag (P);

Affiliation: Laboratory for Experimental Surgery, Department of Pharmacology, University of Zagreb Medical School, Salata 11, Zagreb 10000, Croatia. akrivic2004(-atsign-)yahoo.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (J Orthop Res), published in United States. (Language: eng)

Reference: 2006-May; vol 24 (issue 5) : pp 982-9

Dates: Created 2006/05/01; Completed 2006/06/02; Revised 2006/11/15;

PMID: 16583442, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Achilles Tendon - drug effects; injuries; physiology Adrenal Cortex Hormones - toxicity Animals Anti-Ulcer Agents - pharmacology Biomechanics Male Nitric Oxide - physiology

Nitric Oxide - physiology Peptide Fragments - pharmacology Proteins - pharmacology Rats Rats, Wistar Tendon Injuries - drug therapy; physiopathology Wound Healing - drug effects

Associated Chemicals: Adrenal Cortex Hormones (0) ; Anti-Ulcer Agents (0) ; Peptide Fragments (0) ; Proteins (0) ; Nitric Oxide (10102-43-9) ; BPC 157 (137525-51-0)

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