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Tracing the origin and co-phylogeny of the caliciviruses.
Full Abstract
Caliciviruses infect a wide range of mammalian hosts and include the genus Norovirus, the major cause of food-borne viral gastroenteritis in humans. Using publicly available sequence data and phylogenetic analysis tools, the origins and virus-host co-phylogeny of these viruses were investigated. Here, evidence is presented in support of host switching by caliciviruses, but showing that zoonotic transfer does not appear to have occurred in the history of these viruses. The age or demography of the caliciviruses cannot yet be estimated with any firm degree of support, but further studies of this family, as new dated sequences become available, could provide key information of importance to human health and in understanding the emergence of food-borne disease.
Author information
Author/s: Etherington, Graham J (GJ); Ring, Susan M (SM); Charleston, Michael A (MA); Dicks, Jo (J); Rayward-Smith, Vic J (VJ); Roberts, Ian N (IN);
Affiliation: Department of Food Safety Science, Institute of Food Research, Norwich Research Park, UK.
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of general virology (J Gen Virol), published in England. (Language: eng)
Reference: 2006-May; vol 87 (issue Pt 5) : pp 1229-35
Dates: Created 2006/04/10; Completed 2006/05/18; Revised 2006/11/15;
PMID: 16603525, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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