Research article summary (published 30 Mar 2006):

Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia.

Full Abstract

The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression are associated with outcomes in acute leukemia patients. At diagnosis we examined MDR1, MRP and LRP mRNA expression in bone marrow samples from 71 acute leukemia patients (39 myeloid, 32 lymphoblastic) using nested RT-PCR. The expression of each of these genes was then expressed as a ratio in relation to beta-actin gene expression, and the three genes were categorized as being either 0, 1+, 2+ or 3+. MDR1, MRP and LRP mRNA expression was detected in 23.9%, 83.1% and 45.1 %, respectively. LRP mRNA expression was significantly associated with resistance to induction chemotherapy in acute leukemia patients, and in the AML proportion (p=0.02 and p=0.03, respectively). MRP and high MDR1 mRNA expression was associated with poorer 2-yr survival (p=0.049 and p=0.04, respectively). Patients expressing both MRP and LRP mRNA had poorer outcomes and had worse 2-yr survival. The present data suggest that MDR expression affects complete remission and survival rates in acute leukemia patients. Thus, determination of MDR gene expression at diagnosis appears likely to provide useful prognostic information for acute leukemia patients.

Author information

Author/s: Huh, Hee Jin (HJ); Park, Chan Jeoung (CJ); Jang, Seongsoo (S); Seo, Eul Ju (EJ); Chi, Hyun Sook (HS); Lee, Je Hwan (JH); Lee, Kyoo Hyung (KH); Seo, Jong Jin (JJ); Moon, Hyung Nam (HN); Ghim, Thad (T);

Affiliation: Department of Laboratory Medicine, College of Medicine, University of Ulsan and Asan Medical Center, Pungnap-dong, Seoul, Korea.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of Korean medical science (J Korean Med Sci), published in Korea (South). (Language: eng)

Reference: 2006-Apr; vol 21 (issue 2) : pp 253-8

Dates: Created 2006/04/14; Completed 2006/06/30; Revised 2009/09/01;

PMID: 16614510, status: MEDLINE (last retrieved date: 9/4/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adolescent Adult Aged Base Sequence Child Child, Preschool Female Gene Expression Genes, MDR Humans Infant Leukemia - drug therapy; genetics; mortality

Leukemia - drug therapy; genetics; mortality Leukemia, Myeloid, Acute - drug therapy; genetics; mortality Male Middle Aged Multidrug Resistance-Associated Proteins - genetics Neoplasm Proteins - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; genetics; mortality Prognosis RNA, Messenger - genetics RNA, Neoplasm - genetics Survival Rate Vault Ribonucleoprotein Particles - genetics

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Multidrug Resistance-Associated Proteins (0) ; Neoplasm Proteins (0) ; RNA, Messenger (0) ; RNA, Neoplasm (0) ; Vault Ribonucleoprotein Particles (0) ; major vault protein (0)

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