Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia.

Full Abstract

OBJECTIVE:
To evaluate the efficacy of sleep hygiene and melatonin treatment for initial insomnia in children with attention-deficit/hyperactivity disorder (ADHD).

METHOD:
Twenty-seven stimulant-treated children (6-14 years of age) with ADHD and initial insomnia (>60 minutes) received sleep hygiene intervention. Nonresponders were randomized to a 30-day double-blind, placebo-controlled, crossover trial of 5-mg pharmaceutical-grade melatonin provided by the study's sponsor.

RESULTS:
Sleep hygiene reduced initial insomnia to <60 minutes in 5 cases, with an overall effect size in the group as a whole of 0.67. Analysis of the trial data able to be evaluated showed a significant reduction in initial insomnia of 16 minutes with melatonin relative to placebo, with an effect size of 0.6. Adverse events were generally mild and not different from those recorded with placebo treatment. The effect size of the combined sleep hygiene and melatonin intervention from baseline to 90 days' posttrial was 1.7, with a mean decrease in initial insomnia of 60 minutes. Improved sleep had no demonstrable effect on ADHD symptoms.

CONCLUSION:
Combined sleep hygiene and melatonin was a safe and effective treatment for initial insomnia in children with ADHD taking stimulant medication.

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Author information

Author/s: Weiss, Margaret D (MD); Wasdell, Michael B (MB); Bomben, Melissa M (MM); Rea, Kathleen J (KJ); Freeman, Roger D (RD);

Affiliation: Division of Child Psychiatry, University of British Columbia, Canada. mweiss(-atsign-)cw.bc.ca

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in United States. (Language: eng)

Reference: 2006-May; vol 45 (issue 5) : pp 512-9

Dates: Created 2006/05/03; Completed 2006/07/18; Revised 2006/11/15;

PMID: 16670647, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Arousal - drug effects
Attention Deficit Disorder with Hyperactivity - diagnosis; drug therapy
Child
Circadian Rhythm - drug effects
Cross-Over Studies
Double-Blind Method
Education

Education
Female
Health Education
Humans
Male
Melatonin - adverse effects; therapeutic use
Sleep Initiation and Maintenance Disorders - diagnosis; drug therapy
Treatment Outcome

Associated Chemicals: Melatonin (73-31-4)

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