ADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndrome.

Full Abstract

OBJECTIVE:
To examine prevalence rates of psychopathology in children with velocardiofacial syndrome (VCFS).

METHOD:
One hundred fifty-four children ages 6 to 15 participated in our between-group design with three samples, 84 children with VCFS (37 girls, 47 boys), 32 sibling controls (18 girls, 14 boys), and 38 community controls (12 girls, 26 boys). The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version and several other parent report measures were used to assess for psychopathology.

RESULTS:
Compared to both control samples, children with VCFS had higher prevalence rates of major depressive disorder, attention-deficit/hyperactivity disorder, simple phobias, and enuresis. Additional findings from our analyses include (1) no gender differences in VCFS psychopathology prevalence rates, (2) children with VCFS who have comorbid psychopathology were rated by their parents as having less well-developed executive functions, and (3) across all three samples, the higher the IQ was, the higher the level of global functioning.

CONCLUSIONS:
These findings are consistent with previous research and suggest that major depressive disorder, attention-deficit/hyperactivity disorder, and simple phobias are salient features of the VCFS psychiatric phenotype.

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Author information

Author/s: Antshel, Kevin M (KM); Fremont, Wanda (W); Roizen, Nancy J (NJ); Shprintzen, Robert (R); Higgins, Anne Marie (AM); Dhamoon, Amit (A); Kates, Wendy R (WR);

Affiliation: Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, 13210, USA. AntshelK(-atsign-)upstate.edu

Grants: MH64824 (Agency:NIMH NIH HHS) ; MH65481 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in United States. (Language: eng)

Reference: 2006-May; vol 45 (issue 5) : pp 596-603

Dates: Created 2006/05/03; Completed 2006/07/18; Revised 2007/11/15;

PMID: 16670654, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Attention Deficit Disorder with Hyperactivity - diagnosis; epidemiology; genetics
Child
Chromosome Deletion
Chromosomes, Human, Pair 22
Comorbidity
Cross-Sectional Studies
Depressive Disorder, Major - diagnosis; epidemiology; genetics
DiGeorge Syndrome - diagnosis; epidemiology; genetics
Female

Humans
Intelligence - genetics
Male
Neuropsychological Tests
Personality Assessment - statistics & numerical data
Phobic Disorders - diagnosis; epidemiology; genetics
Psychometrics
Psychopathology
Reference Values
Statistics as Topic

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