Brain tissue water content in patients with idiopathic normal pressure hydrocephalus.

Full Abstract

Relatively little is known regarding the water content of brain tissue in idiopathic normal-pressure hydrocephalus (NPH) patients. The objective of our study was to determine absolute water content non-invasively in hydrocephalic patients, particularly in the anterior and posterior ventricular horns and in the periventricular white matter. Ten patients who were diagnosed and treated for idiopathic NPH in our clinic were selected for study. Magnetic resonance imaging (MRI) techniques were used to obtain anatomical image slices for quantitative brain water measurements. Apparent diffusion coefficient measures were also extracted from regions of interest. To our knowledge, this is the first study to confirm that periventricular lucency seen on MRI represents increased water content in the extracellular space that is markedly elevated prior to shunting.

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Author information

Author/s: Aygok, G (G); Marmarou, A (A); Fatouros, P (P); Young, H (H);

Affiliation: Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA 23298-0508, USA.

Journal and publication information

Publication Type: Clinical Trial; Journal Article

Journal: Acta neurochirurgica. Supplement (Acta Neurochir Suppl), published in Austria. (Language: eng)

Reference: 2006-; vol 96 (issue ) : pp 348-51

Dates: Created 2006/05/04; Completed 2006/06/12;

PMID: 16671483, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Body Water - metabolism
Brain - metabolism; pathology
Cohort Studies
Diffusion
Diffusion Magnetic Resonance Imaging - methods

Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Hydrocephalus, Normal Pressure - diagnosis; metabolism
Male
Tissue Distribution

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