BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.

Full Abstract

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

Author information

Author/s: Kleim, Jeffrey A (JA); Chan, Sheila (S); Pringle, Erin (E); Schallert, Kellan (K); Procaccio, Vincent (V); Jimenez, Richard (R); Cramer, Steven C (SC);

Affiliation: Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA. jkleim(-atsign-)ufl.edu

Grants: 5M01RR 00827-29 (Agency:NCRR NIH HHS) ; NS-45563 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

Journal: Nature neuroscience (Nat Neurosci), published in United States. (Language: eng)

Reference: 2006-Jun; vol 9 (issue 6) : pp 735-7

Dates: Created 2006/05/29; Completed 2006/08/11; Revised 2007/11/14;

PMID: 16680163, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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