Structural birth defects associated with oral clefts in Hawaii, 1986 to 2001.

Full Abstract

OBJECTIVE:
To identify structural birth defects that occur in association with oral clefts.

METHODS:
Data were obtained from a birth defects registry and included all infants and fetuses with cleft palate without cleft lip or cleft lip with or without cleft palate delivered from 1986 to 2001. For 47 specific structural birth defects, rates among oral cleft cases were compared with the rates among all infants and fetuses with major birth defects, excluding those with oral clefts.

RESULTS:
Among cleft palate only cases, the rates were significantly higher than expected for encephalocele, microcephaly, and syndactyly. Among cases of cleft lip with or without cleft palate, the rates were significantly higher than expected for anophthalmia/microphthalmia, single ventricle, reduction deformity of upper limbs, and reduction deformity of lower limbs. When cases of cleft palate only and cleft lip with or without cleft palate were compared as to the rates for particular birth defects, the rates of the defects were either higher or lower than expected in both oral cleft categories for 38 (81%) of the defects.

CONCLUSIONS:
Certain birth defects were more frequently associated with oral clefts than might be expected. For the majority of defects, their patterns of association were similar between cleft palate without cleft lip and cleft lip with or without cleft palate.

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Author information

Author/s: Forrester, Mathias B (MB); Merz, Ruth D (RD);

Affiliation: Hawaii Birth Defects Program, Honolulu, Hawaii 96817-5157, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (Cleft Palate Craniofac J), published in United States. (Language: eng)

Reference: 2006-May; vol 43 (issue 3) : pp 356-62

Dates: Created 2006/05/09; Completed 2006/07/11; Revised 2006/11/15;

PMID: 16681409, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Anophthalmos - complications
Cleft Lip - complications
Cleft Palate - complications
Encephalocele - complications
Hawaii
Heart Defects, Congenital - complications

Humans
Infant, Newborn
Limb Deformities, Congenital - complications
Microcephaly - complications
Retrospective Studies
Syndactyly - complications

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