Long-term neuroprotective effects of carbon dioxide on neonatal rat hypoxic-ischemic brain injury: an experimental study of skilled motor tasks.

Full Abstract

OBJECTIVE:
This study was undertaken to investigate the long-term effect of hypercapnia on neonatal hypoxic-ischemic brain injury, we tested its effect in a neonatal rat hypoxia-ischemia model.

STUDY DESIGN:
The rats were subjected to unilateral carotid artery ligation and exposure to 8% oxygen for 30 minutes. Six percent carbon dioxide was administered to the neonatal rats during unilateral hypoxia-ischemia, and the motor function and neurologic outcomes were determined 3 months later.

RESULTS:
Significant motor functional improvement was observed in the hypercapnic animals, as judged by the Montoya staircase test. The unilateral brain injury was significantly ameliorated in the hypercapnic animals, and this amelioration was well correlated with the motor functional performance. Cerebral blood flow during hypoxia-ischemia, monitored by laser Doppler flowmetry, was better preserved in the hypercapnic animals.

CONCLUSION:
Our results suggest that mild hypercapnia during hypoxia-ischemia may provide long-lasting motor functional as well as neurologic protection for immature brains, possibly by increasing cerebral blood flow during hypoxia.

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Author information

Author/s: Kohzuki, Masatomo (M); Tomimatsu, Takuji (T); Fukuda, Hirotsugu (H); Kanagawa, Takeshi (T); Kanzaki, Toru (T); Shimoya, Koichiro (K); Murata, Yuji (Y);

Affiliation: Department of Obstetrics and Gynecology Osaka University Faculty of Medicine, Suita City, Osaka, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol), published in United States. (Language: eng)

Reference: 2006-Jul; vol 195 (issue 1) : pp 240-5

Dates: Created 2006/07/03; Completed 2006/07/24; Revised 2006/11/15;

PMID: 16681988, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Animals, Newborn
Carbon Dioxide - pharmacology; therapeutic use
Cerebrovascular Circulation - drug effects
Disease Models, Animal
Hypercapnia - physiopathology
Hypoxia-Ischemia, Brain - drug therapy; physiopathology

Laser-Doppler Flowmetry
Motor Activity - drug effects
Motor Skills - drug effects
Neuroprotective Agents - pharmacology; therapeutic use
Rats
Rats, Sprague-Dawley
Recovery of Function

Associated Chemicals: Neuroprotective Agents (0) ; Carbon Dioxide (124-38-9)

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