Aggresomes and autophagy generate sites for virus replication.

Full Abstract

The replication of many viruses is associated with specific intracellular compartments called virus factories or virioplasm. These are thought to provide a physical scaffold to concentrate viral components and thereby increase the efficiency of replication. The formation of virus replication sites often results in rearrangement of cellular membranes and reorganization of the cytoskeleton. Similar rearrangements are seen in cells in response to protein aggregation, where aggresomes and autophagosomes are produced to facilitate protein degradation. Here I review the evidence that some viruses induce aggresomes and autophagosomes to generate sites of replication.

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Author information

Author/s: Wileman, Thomas (T);

Affiliation: School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK. t.wileman(-atsign-)uea.ac.uk

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2006-May; vol 312 (issue 5775) : pp 875-8

Dates: Created 2006/05/12; Completed 2006/05/24; Revised 2007/03/19;

PMID: 16690857, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Autophagy
Cell Membrane Structures - ultrastructure; virology
Cell Nucleus - ultrastructure; virology
Cell Nucleus Structures - ultrastructure; virology
Cytoplasmic Vesicles - physiology; ultrastructure; virology
DNA Viruses - physiology

DNA Viruses - physiology
Models, Biological
Phagosomes - physiology; virology
Proteins - metabolism
RNA Viruses - physiology
Virus Replication

Associated Chemicals: Proteins (0)

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