Ancestry of beagles in lifespan studies of radionuclide toxicity at the University of Utah.

Full Abstract

Analysis of the ancestry of the 1,262 lifespan beagles (LSB) entered into lifespan studies at the Radiobiology Division, University of Utah, beginning in 1952 and ending in 1980, indicated that about 97% of ancestor citations in the various pedigrees were of only 10 breeding animals (breeders) among breeders within the beagle colony. In turn, just 18 AKC-registered "champion" beagles from outside of this colony (founders) accounted for about 98% of all ancestor citations among founders for the LSB. We conclude from this study that the animals used in the lifespan radionuclide experiments can be considered to be somewhat genetically interrelated.

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Author information

Author/s: Lloyd, R D (RD); Taylor, G N (GN); Miller, S C (SC); Bruenger, F W (FW); Jee, W S S (WS);

Affiliation: Department of Radiology, Radiobiology Division, University of Utah, 729 Arapeen Drive #2334, Salt Lake City, UT 84108-1218, USA. ray.lloyd(-atsign-)hsc.utah.edu

Grants: 1R01 CA 66759 (Agency:NCI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Health physics (Health Phys), published in United States. (Language: eng)

Reference: 2006-Jun; vol 90 (issue 6) : pp 580-2

Dates: Created 2006/05/12; Completed 2006/06/08; Revised 2007/11/14;

PMID: 16691106, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Dogs - classification; genetics
Longevity - radiation effects
Pedigree
Radioisotopes - toxicity

Radioisotopes - toxicity
Species Specificity
Toxicity Tests - methods; veterinary
Universities
Utah

Associated Chemicals: Radioisotopes (0)

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