Research article summary (published 29 Apr 2006):

Increase in circulating bone marrow progenitor cells after myocardial infarction.

Full Abstract

BACKGROUND:
Most circulating blood cells expressing the marker CD34 are bone marrow progenitor cells. These cells differentiate into cardiomyocytes, endothelial and smooth muscle cells after myocardial infarction in vivo. Mobilization of bone marrow progenitor cells into the peripheral blood after myocardial infarction may supply these cells to the heart. Rise in CD34+ cell concentrations following myocardial infarction would support the existence of myocardial-initiated mobilization.

METHODS:
Serial measurements of circulating CD34+ cells were made in 42 consecutive patients presenting with first ST-elevation myocardial infarction. Measurement of serum concentrations of monocyte chemoattractant protein-1, stromal derived factor-1, hepatocyte growth factor, interleukin-17 and thrombopoietin was also performed. Samples were drawn on day 1 after myocardial infarction, and on days 4, 8 and 12. Levels of CD34+ cells and cytokines were also measured in 15 controls.

RESULTS:
By day 8, the mean concentration of CD34+ cells rose by 74% above mean control level of 2527 cells/ml, and 41% above day 1 mean (P=0.02). This rise was sustained on day 12 (P=0.05). On day 1, there was a 9.3-fold rise in hepatocyte growth factor above the control level of 589 pg/ml (P=0.002). Hepatocyte growth factor levels declined from the day 1 mean of 6061 to 1485 pg/ml on day 12 (P=0.002). No significant change in stromal derived factor-1, interleukin-17, monocyte chemoattractant protein-1 and thrombopoietin was observed. Elevations in CD34+ cells and hepatocyte growth factor were not related to infarction size as estimated on echocardiography.

CONCLUSIONS:
Elevation in the concentration of circulating CD34+ cells after myocardial infarction suggests that myocardial initiated bone marrow progenitor cell mobilization exists in humans. The cytokines studied in our protocol are not likely to play a direct role in bone marrow progenitor cell mobilization.

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Author information

Author/s: Spevack, Daniel M (DM); Cavaleri, Salvatore (S); Zolotarev, Alexander (A); Liebes, Leonard (L); Inghirami, Giorgio (G); Tunick, Paul A (PA); Kronzon, Itzhak (I);

Affiliation: New York University School of Medicine, New York, New York, USA. dspevack(-atsign-)montefiore.org

Journal and publication information

Publication Type: Journal Article

Journal: Coronary artery disease (Coron Artery Dis), published in England. (Language: eng)

Reference: 2006-May; vol 17 (issue 4) : pp 345-9

Dates: Created 2006/05/18; Completed 2006/11/14; Revised 2007/11/15;

PMID: 16707957, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antigens, CD34 - metabolism Bone Marrow Cells - physiology Case-Control Studies Chemokine CCL2 - blood Chemokine CXCL12 Chemokines, CXC - blood Cytokines - blood Electrocardiography Female

Flow Cytometry - methods Hepatocyte Growth Factor - blood Humans Interleukin-17 - blood Male Middle Aged Myocardial Infarction - blood; pathology Stem Cells - cytology Thrombopoietin - blood

Associated Chemicals: Antigens, CD34 (0) ; CCL2 protein, human (0) ; CXCL12 protein, human (0) ; Chemokine CCL2 (0) ; Chemokine CXCL12 (0) ; Chemokines, CXC (0) ; Cytokines (0) ; Interleukin-17 (0) ; Hepatocyte Growth Factor (67256-21-7) ; Thrombopoietin (9014-42-0)

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