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| Research article summary (published 17 May 2006): |
A cognitive neuroscience perspective on psychopathy: evidence for paralimbic system dysfunction.
Full Abstract
Psychopathy is a complex personality disorder that includes interpersonal and affective traits such as glibness, lack of empathy, guilt or remorse, shallow affect, and irresponsibility, and behavioral characteristics such as impulsivity, poor behavioral control, and promiscuity. Much is known about the assessment of psychopathy; however, relatively little is understood about the relevant brain disturbances. The present review integrates data from studies of behavioral and cognitive changes associated with focal brain lesions or insults and results from psychophysiology, cognitive psychology and cognitive and affective neuroscience in health and psychopathy. The review illustrates that the brain regions implicated in psychopathy include the orbital frontal cortex, insula, anterior and posterior cingulate, amygdala, parahippocampal gyrus, and anterior superior temporal gyrus. The relevant functional neuroanatomy of psychopathy thus includes limbic and paralimbic structures that may be collectively termed 'the paralimbic system'. The paralimbic system dysfunction model of psychopathy is discussed as it relates to the extant literature on psychopathy.
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Author information
Author/s: Kiehl, Kent A (KA);
Affiliation: Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA. kent.kiehl(-atsign-)yale.edu
Grants: 1 R01 MH0705539-01 (Agency:NIMH NIH HHS) ; 1 R01 MH072681-01 (Agency:NIMH NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review
Journal: Psychiatry research (Psychiatry Res), published in Ireland. (Language: eng)
Reference: 2006-Jun; vol 142 (issue 2-3) : pp 107-28
Dates: Created 2006/06/01; Completed 2007/01/12; Revised 2008/04/17;
PMID: 16712954, status: MEDLINE (last retrieval date: 12/26/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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