Influence of intracerebroventricular administration of dopaminergic drugs on morphine state-dependent memory in the step-down passive avoidance test.

Full Abstract

The effects of dopaminergic drugs on morphine state-dependent memory of passive avoidance task were examined in mice. Pre-training administration of morphine (5mg/kg) led to state-dependent learning with impaired memory retrieval on the test day which was reversed by pre-test administration of the same dose of the opiate. The pre-test intracerebroventricular (i.c.v.) administration of the dopamine D1 receptor agonist (SKF38393), dopamine D2 receptor agonist (quinpirole) and dopamine D2 receptor antagonist (sulpiride) not only reversed the effect of pre-training morphine treatment, but also increased this action of the drug. Furthermore, the pre-test i.c.v. administration of dopamine D1 receptor antagonist (SCH23390) prevented the restoration of memory by morphine. In conclusion, the morphine-induced recovery of memory, on the test day, seems to be induced, at least in part, through dopamine receptors.

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Author information

Author/s: Zarrindast, Mohammad-Reza (MR); Bananej, Maryam (M); Khalilzadeh, Azita (A); Fazli-Tabaei, Soheila (S); Haeri-Rohani, Ali (A); Rezayof, Ameneh (A);

Affiliation: Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran. zarinmr(-atsign-)ams.ac.ir

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurobiology of learning and memory (Neurobiol Learn Mem), published in United States. (Language: eng)

Reference: 2006-Nov; vol 86 (issue 3) : pp 286-92

Dates: Created 2006/10/02; Completed 2006/12/07; Revised 2007/10/17;

PMID: 16723261, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Dopamine Agents - administration & dosage; pharmacology
Drug Administration Schedule
Injections, Intraventricular
Male

Male
Mental Recall - drug effects
Mice
Mice, Inbred Strains
Morphine - pharmacology
Narcotics - pharmacology
Receptors, Dopamine D1 - agonists; antagonists & inhibitors; physiology
Receptors, Dopamine D2 - agonists; antagonists & inhibitors; physiology

Associated Chemicals: Dopamine Agents (0) ; Narcotics (0) ; Receptors, Dopamine D1 (0) ; Receptors, Dopamine D2 (0) ; Morphine (57-27-2)

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