Oculomotor plasticity during vestibular compensation does not depend on cerebellar LTD.

Full Abstract

Vestibular paradigms are widely used for investigating mechanisms underlying cerebellar motor learning. These include adaptation of the vestibuloocular reflex (VOR) after visual-vestibular mismatch training and vestibular compensation after unilateral damage to the vestibular apparatus. To date, various studies have shown that VOR adaptation may be supported by long-term depression (LTD) at the parallel fiber to Purkinje cell synapse. Yet it is unknown to what extent vestibular compensation may depend on this cellular process. Here we investigated adaptive gain changes in the VOR and optokinetic reflex during vestibular compensation in transgenic mice in which LTD is specifically blocked in Purkinje cells via expression of a peptide inhibitor of protein kinase C (L7-PKCi mutants). The results demonstrate that neither the strength nor the time course of vestibular compensation are affected by the absence of LTD. In contrast, analysis of vestibular compensation in spontaneous mutants that lack a functional olivo-cerebellar circuit (lurchers) shows that this form of motor learning is severely impaired. We conclude that oculomotor plasticity during vestibular compensation depends critically on intact cerebellar circuitry but not on the occurrence of cerebellar LTD.

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Author information

Author/s: Faulstich, M (M); van Alphen, A M (AM); Luo, C (C); du Lac, S (S); De Zeeuw, C I (CI);

Affiliation: Systems Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of neurophysiology (J Neurophysiol), published in United States. (Language: eng)

Reference: 2006-Sep; vol 96 (issue 3) : pp 1187-95

Dates: Created 2006/08/10; Completed 2006/10/06; Revised 2007/11/15;

PMID: 16723418, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cerebellum - physiology
Long-Term Synaptic Depression - physiology
Mice
Mice, Transgenic
Neuronal Plasticity - physiology

Oculomotor Nerve - physiology
Purkinje Cells - physiology
Reflex, Vestibulo-Ocular - physiology
Restraint, Physical
Synapses - physiology
Vestibule, Labyrinth - physiology

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