[Urine peptide patterns in children with milder types of autism]

(Peptidmønstre i urin hos barn med mildere former for autisme.)

Full Abstract

BACKGROUND:
Autism is a severe developmental disorder. The condition is probably not homogenous. Elevated urine peptides have been found in individuals affected by autism spectrum disorders. This finding may be explained by characteristics of the samples studied. Autistic children without mental retardation (high-functioning autism) or mild mental retardation may represent a more homogenous group among those suffering from autism spectrum disorders. The purpose of this study is to compare urine peptide patterns in this group of patients with healthy controls. This has never been done before.

METHOD:
Urine from the first miction was frozen immediately in order to inhibit bacterial growth and enzymatic degeneration. Peptides from the urine samples were later analysed by high pressure liquid chromatography (HPLC).

RESULTS:
No significant differences in urine peptide values were found between the autism spectrum disorders group and the controls. There was an age dependent decrease in peptides, with values decreasing with the age of the child. Three individuals in the autism group (17%) and one in the familiar control group (0.05%) had high levels of urine peptides. No one in the same age non-familiar control group had elevated levels of urine peptides.

INTERPRETATION:
This study shows that high-functioning autism cannot be identified by the urine peptide pattern.

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Author information

Author/s: Sponheim, Eili (E); Myhre, Anne Margrethe (AM); Reichelt, Karl Ludvig (KL); Aalen, Odd O (OO);

Affiliation: Senter for psykisk helse-barn og unge Kvinne-Barn-Divisjonen, Ullevål universitetssykehus, Sogn senter for barne- og ungdomspsykiatri, Postboks 26 Vinderen, 0319 Oslo. eili.sponheim(-atsign-)medisin.uio.no

Journal and publication information

Publication Type: Comparative Study; English Abstract; Journal Article

Journal: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række (Tidsskr Nor Laegeforen), published in Norway. (Language: nor)

Reference: 2006-May; vol 126 (issue 11) : pp 1475-7

Dates: Created 2006/05/29; Completed 2006/06/29; Revised 2008/07/16;

PMID: 16732341, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Asperger Syndrome - urine
Autistic Disorder - urine
Biological Markers - urine
Child
Child, Preschool

Child, Preschool
Chromatography, High Pressure Liquid
Female
Humans
Male
Peptides - urine

Associated Chemicals: Biological Markers (0) ; Peptides (0)

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