Bioanalytical interaction studies executed by preincubation affinity capillary electrophoresis.

Full Abstract

The versatility of CE is beneficial for the study of many types of molecular interactions, because different experimental designs can be made to suit the characteristics of a particular interaction. A very versatile starting point is the preequilibration type of affinity CE that has been used extensively for characterizing biomolecular interactions in the last 15 years. We review this field here and include a comprehensive overview of the existing preincubation ACE modes including their advantages and limitations as well as the methodological developments and applications within the bioanalytical field.

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Author information

Author/s: Ostergaard, Jesper (J); Heegaard, Niels H H (NH);

Affiliation: Department of Pharmaceutics and Analytical Chemistry, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark. joe(-atsign-)dfuni.dk

Journal and publication information

Publication Type: Journal Article; Review

Journal: Electrophoresis (Electrophoresis), published in Germany. (Language: eng)

Reference: 2006-Jul; vol 27 (issue 13) : pp 2590-608

Dates: Created 2006/08/14; Completed 2006/09/15;

PMID: 16732622, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Electrophoresis, Capillary - methods
Humans
Nucleic Acids - analysis; metabolism
Protein Interaction Mapping
Proteins - analysis; metabolism

Associated Chemicals: Carbohydrates (0) ; Nucleic Acids (0) ; Proteins (0)

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