Longitudinal study of mortality predictors in Parkinson's disease in Nigerians.

Full Abstract

Parkinson's disease (PD) has been associated with increased mortality. The mortality in Nigerians has not been described. This study was designed to assess mortality in PD and relate it to gender, age at onset of PD and at baseline, and duration of PD. A case-control study of 28 PD and 28 age- and sex-matched controls from similar geographic locality was conducted. Baseline clinical characteristics of the PD patients and controls were documented at study inception. Cases and controls selected between January and June 1997 were followed up after a 6-year interval (May 2002). The case fatality rate (CFR) in PD was 25% compared to 7.1% in controls (Mantel-Haenszel test, P=0.07). PD survivors (compared to PD patients who died) were significantly younger both at study onset (mean age 59.8 +/- 10.3 v. 72.3 +/- 6.8; P=0.002) and at onset of PD (mean age 57.3 +/- 10.3 v. 69.3 +/- 6.5; P=0.003), and had significantly less severe disease at baseline (mean Hoehn & Yahr stage 2.1 < or = 0.7 v. 2.9 +/- 1.1; P=0.04). CFR was significantly higher in PD cases aged =70 years at study onset (Mantel-Haenszel test, P=0.004) and at onset of PD (Mantel-Haenszel test, P=0.001), but not in age-matched controls. PD affecting Nigerians is associated with increased mortality as has been demonstrated in other geographic locations. Factors associated with increased mortality include advanced age, older age at onset of PD, and more severe disease.

Learn Faster Today Improve your study skills

Author information

Author/s: Okubadejo, N U (NU); Ojini, F I (FI); Danesi, M A (MA);

Affiliation: Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria. nsnsluth(-atsign-)yahoo.com

Journal and publication information

Publication Type: Journal Article

Journal: African journal of medicine and medical sciences (Afr J Med Med Sci), published in Nigeria. (Language: eng)

Reference: 2005-Dec; vol 34 (issue 4) : pp 365-9

Dates: Created 2006/06/06; Completed 2006/07/11;

PMID: 16752667, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Male
Middle Aged
Nigeria - epidemiology
Outpatient Clinics, Hospital - utilization
Parkinson Disease - mortality; physiopathology
Prognosis
Prospective Studies
Risk Assessment
Risk Factors

These are the highest related articles currently in the database:

Mortality and cancer incidence in patients with Parkinson's disease. 30 May 2000
Parkinson's disease and levodopa. A five-year follow-up and review. 30 Aug 1974
Epidemiologic studies of Parkinson's disease. II. A hospital-based survey. 30 Mar 1972
Survival and cause of death in a cohort of patients with parkinsonism: possible clues to aetiology? 27 Feb 1995
Long-term survival of Parkinson's disease: a population-based study. 16 Jul 2005
Dementia and survival in Parkinson disease: a 12-year population study. 23 Mar 2008
Bromocriptine lessens the incidence of mortality in L-dopa-treated parkinsonian patients: prado-study discontinued. 30 Dec 1991
Changing epidemiology of Parkinson's disease: predicted effects of levodopa treatment. 27 Feb 1979
Environmental risk factors for Parkinson's disease: the epidemiologic evidence. 30 Jul 1987
A clinical survey of parkinsonism in Iceland. 30 Dec 1966

See 100+ related articles.