Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis in 2 patients with end-stage renal disease on hemodialysis.

Full Abstract

Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF) is a newly recognized disorder occurring in patients with renal failure. It is manifested by progressive cutaneous and systemic fibrosis involving the extremities and the trunk with usual sparing of the face and internal organs. NFD/NSF can lead to joint contractures and painful disability. The etiology is unknown and there are no proven effective treatments. NFD/NSF must be distinguished from other clinically similar disorders such as scleroderma, scleromyxedema, and eosinophilic fasciitis among a myriad of others. NFD/NSF can pose many diagnostic challenges to physicians; however, a team of experienced rheumatologists, nephrologists, dermatologists, and dermatopathologists is essential in identifying this disorder. We report 2 new cases of NFD/NSF in patients on hemodialysis.

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Author information

Author/s: Kim, Richard H (RH); Ma, L (L); Hayat, S Q (SQ); Ahmed, M M (MM);

Affiliation: Center of Excellence in Arthritis and Rheumatology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. ojingoh(-atsign-)hotmail.com

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol), published in United States. (Language: eng)

Reference: 2006-Jun; vol 12 (issue 3) : pp 134-6

Dates: Created 2006/06/06; Completed 2006/11/09; Revised 2008/04/10;

PMID: 16755242, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Biopsy
Fibrosis
Humans
Kidney Failure, Chronic - complications; therapy

Kidney Failure, Chronic - complications; therapy
Male
Middle Aged
Renal Dialysis
Skin Diseases - etiology; pathology

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