[Spectrum of neuropsychiatric features associated with velocardiofacial syndrome (Deletion 22q11.2)]

(Das neuropsychiatrische Spektrum des Velokardiofazialen Syndroms (Deletion 22q11.2).)

Full Abstract

Microdeletion 22q11.2 (22q11DS) is the most frequent chromosomal deletion known in man. Velocardiofacial syndrome is one of numerous clinical syndromes that can be attributed to this micro deletion. There is an increasing recognition of associations with neuropsychiatric disorders. Particularly, schizophrenic psychosis, attention-deficit/hyperactivity disorder (ADHD), intellectual impairment and learning disabilities, seizures and motoric abnormalities have been identified in patients with 22q11DS. Recent studies supported the association of schizophrenia and 22q11DS, but the pathogenetic implications for idiopathic schizophrenia are still controversial. We report on two clinical cases in which psychotic symptoms led to the molecularcytogenetic diagnosis of microdeletion 22q11.2. Additionally, this article gives a systematic review of literature regarding psychiatric disorders, neurologic symptoms and partly corresponding morphological brain abnormalities in 22q11 deletion syndromes.

Author information

Author/s: Sieberer, M (M); Runte, I (I); Wilkening, A (A); Pabst, B (B); Ziegenbein, M (M); Haltenhof, H (H);

Affiliation: Abteilung Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover. dr.marcel.sieberer(-atsign-)agnes-karll-krankenhaus.de

Journal and publication information

Publication Type: Case Reports; English Abstract; Journal Article; Review

Journal: Fortschritte der Neurologie-Psychiatrie (Fortschr Neurol Psychiatr), published in Germany. (Language: ger)

Reference: 2006-May; vol 74 (issue 5) : pp 263-74

Dates: Created 2006/06/06; Completed 2006/06/21; Revised 2006/11/15;

PMID: 16758538, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.