Familial clustering in subgroups of gastric cancer stratified by histology, age group and location.

Full Abstract

AIM:
To assess the risk of gastric cancer in a Japanese patient population with the disease by stratification with histology, age, tumour location and the association with family history of gastric or non-gastric tumours.

METHODS:
A retrospective analysis of 1400 consecutive patients with gastric cancer and 13,467 age- and gender-matched controls from a pre-recorded database using conditional logistic regression models.

RESULTS:
Young patients (< or = 43 years of age) with gastric cancer of intestinal type had a strong association with family history of gastric cancer in first degree-relatives (OR=12.5). Moreover, when a history of gastric cancer was observed in both parents, there was an increased risk of gastric cancer intestinal type (OR=7.8), more commonly in the proximal and mid-stomach. In contrast, there was an increased risk of diffuse-type cancer when both parents suffered non-gastric cancers (OR=2.1).

CONCLUSION:
These data suggest that the degree of familial clustering differ in gastric cancer subgroups stratified by histology, age, and stomach location in this Japanese population.

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Author information

Author/s: Eto, K (K); Ohyama, S (S); Yamaguchi, T (T); Wada, T (T); Suzuki, Y (Y); Mitsumori, N (N); Kashiwagi, H (H); Anazawa, S (S); Yanaga, K (K); Urashima, M (M);

Affiliation: Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan.

Journal and publication information

Publication Type: Journal Article

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol), published in England. (Language: eng)

Reference: 2006-Sep; vol 32 (issue 7) : pp 743-8

Dates: Created 2006/08/28; Completed 2006/11/30; Revised 2007/07/02;

PMID: 16762526, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Japan - epidemiology
Male
Middle Aged
Odds Ratio
Stomach Neoplasms - epidemiology; genetics; pathology

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